Nicotine Addiction Through a Neurogenomic Prism: Ethics, Public Health, and Smoking

Overview

Journal Nicotine Tob Res

Publisher Oxford University Press

Specialty Public Health

Date 2005 Jul 23

PMID 16036275

Citations 17

Authors

Lorraine Caron

Katrina Karkazis

Thomas A Raffin

Gary Swan

Barbara A Koenig

Affiliations

Soon will be listed here.

Abstract

Studies are under way to examine the neurogenetic factors contributing to smoking behaviors. The combined approaches of genomics, molecular biology, neuroscience, and pharmacology are expected to fuel developments in pharmacogenetics, to create new genetic tests, and ultimately to provide the basis for innovative strategies for smoking cessation and prevention. The emergence of a neurogenomic understanding of nicotine addiction is likely to induce fundamental changes in popular, clinical, and public health views of smoking, which could significantly shape existing practices and policies to reduce tobacco use. Still a nascent area of research, nicotine addiction provides an excellent case study through which to anticipate key ethical and policy issues in both behavioral genetics and the neurogenomics of addictive behaviors.

Citing Articles

Dopamine in the Regulation of Glucose Homeostasis, Pathogenesis of Type 2 Diabetes, and Chronic Conditions of Impaired Dopamine Activity/Metabolism: Implication for Pathophysiological and Therapeutic Purposes.

Lisco G, De Tullio A, Iovino M, Disoteo O, Guastamacchia E, Giagulli V Biomedicines. 2023; 11(11).

PMID: 38001993 PMC: 10669051. DOI: 10.3390/biomedicines11112993.

Smoking under hypoxic conditions: a potent environmental risk factor for inflammatory and autoimmune diseases.

Hussain M, Tripathi V Mil Med Res. 2018; 5(1):11.

PMID: 29598831 PMC: 5877397. DOI: 10.1186/s40779-018-0158-5.

Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats.

Han W, Wang T, Chen H Sci Rep. 2017; 7(1):8052.

PMID: 28808247 PMC: 5556091. DOI: 10.1038/s41598-017-08291-5.

Inhibitors of ceramide de novo biosynthesis rescue damages induced by cigarette smoke in airways epithelia.

Zulueta A, Caretti A, Campisi G, Brizzolari A, Abad J, Paroni R Naunyn Schmiedebergs Arch Pharmacol. 2017; 390(7):753-759.

PMID: 28409208 DOI: 10.1007/s00210-017-1375-2.

Neurogenomics: An opportunity to integrate neuroscience, genomics and bioinformatics research in Africa.

Karikari T, Aleksic J Appl Transl Genom. 2016; 5:3-10.

PMID: 26937352 PMC: 4745356. DOI: 10.1016/j.atg.2015.06.004.

References

Greely H . Legal, ethical, and social issues in human genome research. Annu Rev Anthropol. 2005; 27:473-502. DOI: 10.1146/annurev.anthro.27.1.473. View

Schork N, Fallin D, Thiel B, Xu X, Broeckel U, Jacob H . The future of genetic case-control studies. Adv Genet. 2000; 42:191-212. DOI: 10.1016/s0065-2660(01)42023-2. View

Noble E, Zhang X, Ritchie T, Sparkes R . Haplotypes at the DRD2 locus and severe alcoholism. Am J Med Genet. 2000; 96(5):622-31. DOI: 10.1002/1096-8628(20001009)96:5<622::aid-ajmg7>3.0.co;2-5. View

Miller N, Guttman J, Chawla S . Integration of generalized vulnerability to drug and alcohol addiction. J Addict Dis. 1997; 16(4):7-22. DOI: 10.1080/10550889709511140. View

Jorm A, Henderson A, Jacomb P, Christensen H, Korten A, Rodgers B . Association of smoking and personality with a polymorphism of the dopamine transporter gene: results from a community survey. Am J Med Genet. 2000; 96(3):331-4. DOI: 10.1002/1096-8628(20000612)96:3<331::aid-ajmg19>3.0.co;2-0. View

Hyman S . The millennium of mind, brain, and behavior. Arch Gen Psychiatry. 2000; 57(1):88-9. DOI: 10.1001/archpsyc.57.1.88. View

Spitz M, Shi H, Yang F, Hudmon K, Jiang H, Chamberlain R . Case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients. J Natl Cancer Inst. 1998; 90(5):358-63. DOI: 10.1093/jnci/90.5.358. View

Rothenberg K . Breast cancer, the genetic "quick fix," and the Jewish community. Ethical, legal, and social challenges. Health Matrix Clevel. 1997; 7(1):97-124. View

Cheng L, Swan G, Carmelli D . A genetic analysis of smoking behavior in family members of older adult males. Addiction. 2000; 95(3):427-35. DOI: 10.1046/j.1360-0443.2000.95342713.x. View

10.

Kessler D, Barnett P, Witt A, Zeller M, Mande J, Schultz W . The legal and scientific basis for FDA's assertion of jurisdiction over cigarettes and smokeless tobacco. JAMA. 1997; 277(5):405-9. View

11.

Cowan W, Kandel E . Prospects for neurology and psychiatry. JAMA. 2001; 285(5):594-600. DOI: 10.1001/jama.285.5.594. View

12.

Levin B, Fleischman A . Public health and bioethics: the benefits of collaboration. Am J Public Health. 2002; 92(2):165-7. PMC: 1447034. DOI: 10.2105/ajph.92.2.165. View

13.

Waldman I, Slutske W . Antisocial behavior and alcoholism: a behavioral genetic perspective on comorbidity. Clin Psychol Rev. 2000; 20(2):255-87. DOI: 10.1016/s0272-7358(99)00029-x. View

14.

Holtzman N, Marteau T . Will genetics revolutionize medicine?. N Engl J Med. 2000; 343(2):141-4. DOI: 10.1056/NEJM200007133430213. View

15.

Pidoplichko V, Debiasi M, Williams J, Dani J . Nicotine activates and desensitizes midbrain dopamine neurons. Nature. 1997; 390(6658):401-4. DOI: 10.1038/37120. View

16.

Loriot M, Rebuissou S, Oscarson M, Cenee S, Miyamoto M, Ariyoshi N . Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population. Pharmacogenetics. 2001; 11(1):39-44. DOI: 10.1097/00008571-200102000-00005. View

17.

Lerman C, Caporaso N, Audrain J, Main D, Boyd N, Shields P . Interacting effects of the serotonin transporter gene and neuroticism in smoking practices and nicotine dependence. Mol Psychiatry. 2000; 5(2):189-92. DOI: 10.1038/sj.mp.4000672. View

18.

Landrine H, Klonoff E . Racial discrimination and cigarette smoking among Blacks: findings from two studies. Ethn Dis. 2000; 10(2):195-202. View

19.

Slotkin T, Pinkerton K, Auman J, Qiao D, Seidler F . Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. Brain Res Dev Brain Res. 2002; 133(2):175-9. DOI: 10.1016/s0165-3806(02)00281-x. View

20.

Heishman S . Behavioral and cognitive effects of smoking: relationship to nicotine addiction. Nicotine Tob Res. 2002; 1 Suppl 2:S143-7; discussion S165-6. DOI: 10.1080/14622299050011971. View