Abnormal Brain and Muscle Energy Metabolism Shown by 31P Magnetic Resonance Spectroscopy in Patients Affected by Migraine with Aura

Overview

Journal Neurology

Specialty Neurology

Date 1992 Jun 1

PMID 1603349

Citations 50

Authors

B Barbiroli

P Montagna

P Cortelli

R Funicello

S Iotti

L Monari

G Pierangeli

P Zaniol

E Lugaresi

Affiliations

Soon will be listed here.

Abstract

We studied brain and muscle energy metabolism by phosphorus 31 magnetic resonance spectroscopy (31P-MRS) in 12 patients affected by migraine with aura (classic migraine) in interictal periods. Brain 31P-MRS disclosed a low phosphocreatine content in all patients, accompanied by high adenosine diphosphate concentration, a high percentage of V/Vmax (adenosine triphosphate), and a low phosphorylation potential--features showing an unstable state of metabolism in classic migraine. Abnormal muscle mitochondrial function, in the absence of clinical signs of muscle impairment, was present in nine of the 12 patients examined.

Citing Articles

H-MRS reveals abnormal energy metabolism and excitatory-inhibitory imbalance in a chronic migraine-like state induced by nitroglycerin in mice.

Gao J, Wang D, Zhu C, Wang J, Wang T, Xu Y J Headache Pain. 2024; 25(1):163.

PMID: 39350002 PMC: 11441011. DOI: 10.1186/s10194-024-01872-6.

AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization.

Lu G, Xiao S, Meng F, Zhang L, Chang Y, Zhao J J Headache Pain. 2024; 25(1):29.

PMID: 38454376 PMC: 10921743. DOI: 10.1186/s10194-024-01739-w.

Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine.

Xie W, Li R, Tang W, Ma Z, Miao S, Li C J Headache Pain. 2023; 24(1):122.

PMID: 37667199 PMC: 10478405. DOI: 10.1186/s10194-023-01646-6.

Evaluating migraine with typical aura with neuroimaging.

Karsan N, Silva E, Goadsby P Front Hum Neurosci. 2023; 17:1112790.

PMID: 37025972 PMC: 10070832. DOI: 10.3389/fnhum.2023.1112790.

Migraine signaling pathways: purine metabolites that regulate migraine and predispose migraineurs to headache.

Biringer R Mol Cell Biochem. 2023; 478(12):2813-2848.

PMID: 36947357 DOI: 10.1007/s11010-023-04701-7.