Triplet Excited States As Chiral Reporters for the Binding of Drugs to Transport Proteins

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2005 Jul 21

PMID 16028901

Citations 7

Authors

M Consuelo Jimenez

Miguel A Miranda

Ignacio Vaya

Affiliations

Soon will be listed here.

Abstract

The triplet excited state of flurbiprofen methyl ester (FBPMe) has been used as a chiral reporter for the two binding sites of human serum albumin (HSA). The occupation level of the binding sites has been estimated from regression analysis of the triplet decays at several [FBPMe]/[HSA] ratios. The data agree with two high affinity binding sites (I and II) that are populated to a different extent. A remarkable stereodifferentiation has been found in the drug triplet lifetimes within the protein microenvironment.

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