"Bicellar" Lipid Mixtures As Used in Biochemical and Biophysical Studies

Overview

Journal Naturwissenschaften

Specialty Science

Date 2005 Jul 16

PMID 16021408

Citations 21

Authors

John Katsaras

Thad A Harroun

Jeremy Pencer

Mu-Ping Nieh

Affiliations

Soon will be listed here.

Abstract

Over the past decade "bicellar" lipid mixtures composed of the long-chain dimyristoyl phosphatidylcholine (DMPC) and the short-chain dihexanoyl PC (DHPC) molecules have emerged as a powerful medium for studying membrane associated, biologically relevant macromolecules and assemblies. Depending on temperature, lipid concentration and composition these lipid mixtures can assume a variety of morphologies, some of them alignable in the presence of a magnetic field. This article will examine the biophysical studies that have elucidated the various morphologies assumed by these lipid mixtures, and their use in the biochemical studies of biomolecules.

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