» Articles » PMID: 16011512

Paired Immunoglobulin-like Receptors and Their MHC Class I Recognition

Overview
Journal Immunology
Date 2005 Jul 14
PMID 16011512
Citations 95
Authors
Affiliations
Soon will be listed here.
Abstract

The immunoglobulin-like receptors provide positive and negative regulation of immune cells upon recognition of various ligands, thus enabling those cells to respond properly to extrinsic stimuli. Murine paired immunoglobulin-like receptor (PIR)-A and PIR-B, a typical receptor pair of the immunoglobulin-like receptor family, are expressed on a wide range of cells in the immune system, such as B cells, mast cells, macrophages and dendritic cells, mostly in a pair-wise fashion. The PIR-A requires the homodimeric Fc receptor common gamma chain for its efficient cell-surface expression and for the delivery of an activation signal. In contrast, PIR-B inhibits receptor-mediated activation signals in vitro upon engagement with other activating-type receptors, such as the antigen receptor on B cells and the high-affinity Fc receptor for immunoglobulin E on mast cells. Recent identification of major histocompatibility complex (MHC) class I molecules as the physiological ligands for PIR has enabled us to attribute various immunological phenotypes observed in PIR-B-deficient mice to the consequences of the absence of a balanced interaction between PIR and MHC class I molecules expressed ubiquitously. Thus, PIR-A and PIR-B constitute a novel and physiologically important MHC class I recognition system.

Citing Articles

Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway.

Meng X, Li D, Kan R, Xiang Y, Pan L, Guo Y J Neuroinflammation. 2024; 21(1):192.

PMID: 39095838 PMC: 11297729. DOI: 10.1186/s12974-024-03183-8.


Epithelial recognition and elimination against aberrant cells.

Ayukawa S, Kamoshita N, Maruyama T Semin Immunopathol. 2024; 45(4-6):521-532.

PMID: 38411739 DOI: 10.1007/s00281-024-01001-0.


CaSSiDI: novel single-cell "Cluster Similarity Scoring and Distinction Index" reveals critical functions for PirB and context-dependent Cebpb repression.

Nechanitzky R, Ramachandran P, Nechanitzky D, Li W, Wakeham A, Haight J Cell Death Differ. 2024; 31(3):265-279.

PMID: 38383888 PMC: 10923835. DOI: 10.1038/s41418-024-01268-8.


Immune receptors and aging brain.

Djurisic M Biosci Rep. 2024; 44(2).

PMID: 38299364 PMC: 10866841. DOI: 10.1042/BSR20222267.


Human leukocyte immunoglobulin-like receptors in health and disease.

Redondo-Garcia S, Barritt C, Papagregoriou C, Yeboah M, Frendeus B, Cragg M Front Immunol. 2023; 14:1282874.

PMID: 38022598 PMC: 10679719. DOI: 10.3389/fimmu.2023.1282874.


References
1.
Maliszewski C, March C, Schoenborn M, Gimpel S, Shen L . Expression cloning of a human Fc receptor for IgA. J Exp Med. 1990; 172(6):1665-72. PMC: 2188749. DOI: 10.1084/jem.172.6.1665. View

2.
Timms J, Carlberg K, Gu H, Chen H, Kamatkar S, Nadler M . Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages. Mol Cell Biol. 1998; 18(7):3838-50. PMC: 108968. DOI: 10.1128/MCB.18.7.3838. View

3.
Ho L, Uehara T, Chen C, Kubagawa H, Cooper M . Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B. Proc Natl Acad Sci U S A. 1999; 96(26):15086-90. PMC: 24777. DOI: 10.1073/pnas.96.26.15086. View

4.
Takai T, Li M, Sylvestre D, Clynes R, Ravetch J . FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell. 1994; 76(3):519-29. DOI: 10.1016/0092-8674(94)90115-5. View

5.
Dennis Jr G, Kubagawa H, Cooper M . Paired Ig-like receptor homologs in birds and mammals share a common ancestor with mammalian Fc receptors. Proc Natl Acad Sci U S A. 2000; 97(24):13245-50. PMC: 27210. DOI: 10.1073/pnas.230442897. View