» Articles » PMID: 1601013

Microscopic Observations on Tracheal Aspirates from Ventilated Neonates. II. The Onset of Bronchopulmonary Dysplasia and Other Changes

Overview
Journal Eur J Pediatr
Specialty Pediatrics
Date 1992 Mar 1
PMID 1601013
Citations 2
Authors
Affiliations
Soon will be listed here.
Abstract

A total of 450 undiluted and unprocessed tracheal aspirates from 120 intubated infants were examined microscopically for evidence of bronchopulmonary dysplasia and other changes. In 19 infants desquamated sheets of dysplastic epithelium in the fresh aspirate provided an early indication of developing bronchopulmonary dysplasia. Examination of unstained tracheal aspirates can provide, within minutes, information not only about the onset and development of bronchopulmonary dysplasia, but also provide evidence for milk or formula aspiration and for gastro-oesophageal reflux.

Citing Articles

Use of Optical Redox Imaging to Quantify Alveolar Macrophage Redox State in Infants: Proof of Concept Experiments in a Murine Model and Human Tracheal Aspirates Samples.

Xu H, Gonzalves D, Hoffman J, Baur J, Li L, Jensen E Antioxidants (Basel). 2024; 13(5).

PMID: 38790651 PMC: 11117937. DOI: 10.3390/antiox13050546.


Sonographic prediction of chronic lung disease in the premature undergoing mechanical ventilation.

Avni E, Cassart M, De Maertelaer V, Rypens F, Vermeylen D, Gevenois P Pediatr Radiol. 1996; 26(7):463-9.

PMID: 8662064 DOI: 10.1007/BF01377203.

References
1.
Merritt T, Puccia J, Stuard I . Cytologic evaluation of pulmonary effluent in neonates with respiratory distress syndrome and bronchopulmonary dysplasia. Acta Cytol. 1981; 25(6):631-9. View

2.
Goldstein R, Fine A . Fibrotic reactions in the lung: the activation of the lung fibroblast. Exp Lung Res. 1986; 11(4):245-61. DOI: 10.3109/01902148609062828. View

3.
Jacobson W, South M, Hughes G, Davies R, Morley C . Tracheal aspirates from neonates during endotracheal intubation: detection of surfactant by polarized light microscopy. J Pediatr. 1988; 113(2):368-72. DOI: 10.1016/s0022-3476(88)80286-5. View

4.
Bruce M, Martin R, Boat T . Concentrations of alpha 1-proteinase inhibitor and alpha 2-macroglobulin in serum and lung secretions of intubated infants. Pediatr Res. 1984; 18(1):35-40. View

5.
Ogden B, Murphy S, Saunders G, Pathak D, Johnson J . Neonatal lung neutrophils and elastase/proteinase inhibitor imbalance. Am Rev Respir Dis. 1984; 130(5):817-21. DOI: 10.1164/arrd.1984.130.5.817. View