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Synthesis and Degradation of Nucleic Acid Components by Formamide and Cosmic Dust Analogues

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Journal Chembiochem
Specialty Biochemistry
Date 2005 Jul 9
PMID 16003804
Citations 15
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Abstract

We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formamide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.

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