Chemokine Receptor Internalization and Intracellular Trafficking

Overview

Journal Cytokine Growth Factor Rev

Date 2005 Jul 7

PMID 15998596

Citations 84

Authors

Nicole F Neel

Evemie Schutyser

Jiqing Sai

Guo-Huang Fan

Ann Richmond

Affiliations

Soon will be listed here.

Abstract

The internalization and intracellular trafficking of chemokine receptors have important implications for the cellular responses elicited by chemokine receptors. The major pathway by which chemokine receptors internalize is the clathrin-mediated pathway, but some receptors may utilize lipid rafts/caveolae-dependent internalization routes. This review discusses the current knowledge and controversies regarding these two different routes of endocytosis. The functional consequences of internalization and the regulation of chemokine receptor recycling will also be addressed. Modifications of chemokine receptors, such as palmitoylation, ubiquitination, glycosylation, and sulfation, may also impact trafficking, chemotaxis and signaling. Finally, this review will cover the internalization and trafficking of viral and decoy chemokine receptors.

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References

Wang J, Babcock G, Choe H, Farzan M, Sodroski J, Gabuzda D . N-linked glycosylation in the CXCR4 N-terminus inhibits binding to HIV-1 envelope glycoproteins. Virology. 2004; 324(1):140-50. DOI: 10.1016/j.virol.2004.03.005. View

Geras-Raaka E, Arvanitakis L, Bais C, Cesarman E, Mesri E, Gershengorn M . Inhibition of constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor by protein kinases in mammalian cells in culture. J Exp Med. 1998; 187(5):801-6. PMC: 2212177. DOI: 10.1084/jem.187.5.801. View

Schraufstatter I, Burger M, Hoch R, Oades Z, Takamori H . Importance of the carboxy-terminus of the CXCR2 for signal transduction. Biochem Biophys Res Commun. 1998; 244(1):243-8. DOI: 10.1006/bbrc.1998.8246. View

Mack M, Luckow B, Nelson P, Cihak J, Simmons G, Clapham P . Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J Exp Med. 1998; 187(8):1215-24. PMC: 2212227. DOI: 10.1084/jem.187.8.1215. View

Ferguson S, Zhang J, Barak L, Caron M . Molecular mechanisms of G protein-coupled receptor desensitization and resensitization. Life Sci. 1998; 62(17-18):1561-5. DOI: 10.1016/s0024-3205(98)00107-6. View

Krupnick J, Benovic J . The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol. 1998; 38:289-319. DOI: 10.1146/annurev.pharmtox.38.1.289. View

Ren M, Xu G, Zeng J, Adesnik M, Sabatini D . Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc Natl Acad Sci U S A. 1998; 95(11):6187-92. PMC: 27621. DOI: 10.1073/pnas.95.11.6187. View

Geras-Raaka E, Varma A, Ho H, Clark-Lewis I, Gershengorn M . Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. J Exp Med. 1998; 188(2):405-8. PMC: 2212452. DOI: 10.1084/jem.188.2.405. View

Richardson R, Pridgen B, Haribabu B, Ali H, Snyderman R . Differential cross-regulation of the human chemokine receptors CXCR1 and CXCR2. Evidence for time-dependent signal generation. J Biol Chem. 1998; 273(37):23830-6. DOI: 10.1074/jbc.273.37.23830. View

10.

Gershengorn M, Geras-Raaka E, Varma A, Clark-Lewis I . Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture. J Clin Invest. 1998; 102(8):1469-72. PMC: 508995. DOI: 10.1172/JCI4461. View

11.

Rosenkilde M, Kledal T, Brauner-Osborne H, Schwartz T . Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74. J Biol Chem. 1999; 274(2):956-61. DOI: 10.1074/jbc.274.2.956. View

12.

Casanova J, Wang X, Kumar R, Bhartur S, Navarre J, Woodrum J . Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell. 1999; 10(1):47-61. PMC: 25153. DOI: 10.1091/mbc.10.1.47. View

13.

Kledal T, Rosenkilde M, Schwartz T . Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broad-spectrum receptor US28. FEBS Lett. 1999; 441(2):209-14. DOI: 10.1016/s0014-5793(98)01551-8. View

14.

Brown D, London E . Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol. 1999; 14:111-36. DOI: 10.1146/annurev.cellbio.14.1.111. View

15.

Oppermann M, Mack M, Proudfoot A, Olbrich H . Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. J Biol Chem. 1999; 274(13):8875-85. DOI: 10.1074/jbc.274.13.8875. View

16.

Farzan M, Mirzabekov T, Kolchinsky P, Wyatt R, Cayabyab M, Gerard N . Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. Cell. 1999; 96(5):667-76. DOI: 10.1016/s0092-8674(00)80577-2. View

17.

Laporte S, Oakley R, Zhang J, Holt J, Ferguson S, Caron M . The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc Natl Acad Sci U S A. 1999; 96(7):3712-7. PMC: 22359. DOI: 10.1073/pnas.96.7.3712. View

18.

Sheff D, Daro E, Hull M, Mellman I . The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions. J Cell Biol. 1999; 145(1):123-39. PMC: 2148223. DOI: 10.1083/jcb.145.1.123. View

19.

Yang W, Wang D, Richmond A . Role of clathrin-mediated endocytosis in CXCR2 sequestration, resensitization, and signal transduction. J Biol Chem. 1999; 274(16):11328-33. DOI: 10.1074/jbc.274.16.11328. View

20.

Zimmermann N, Conkright J, Rothenberg M . CC chemokine receptor-3 undergoes prolonged ligand-induced internalization. J Biol Chem. 1999; 274(18):12611-8. DOI: 10.1074/jbc.274.18.12611. View