Closing in on a Breast Cancer Gene on Chromosome 17q

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1992 Jun 1

PMID 1598904

Citations 69

Authors

J M Hall

L Friedman

C Guenther

M K Lee

J L Weber

D M Black

M C King

Affiliations

Soon will be listed here.

Abstract

Linkage of early-onset familial breast and ovarian cancer to 11 markers on chromosome 17q12-q21 defines an 8-cM region which is very likely to include the disease gene BRCA 1. The most closely linked marker is D17S579, a highly informative CA repeat polymorphism. D17S579 has no recombinants with inherited breast or ovarian cancer in 79 informative meioses in the seven families with early-onset disease (lod score 9.12 at zero recombination). There is no evidence for linkage heterogeneity in the families with early-onset disease. The proportion of older-onset breast cancer attributable to BRCA 1 is not yet determinable, because both inherited and sporadic cases occur in older-onset families.

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