Role of Nuclear Factor-kappa B in Melanoma

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 2005 Jun 30

PMID 15986139

Citations 72

Authors

Katayoun I Amiri

Ann Richmond

Affiliations

Soon will be listed here.

Abstract

Nuclear Factor-kappa B (NF-kappa B) is an inducible transcription factor that regulates the expression of many genes involved in the immune response. Recently, NF-kappa B activity has been shown to be upregulated in many cancers, including melanoma. Data indicate that the enhanced activation of NF-kappa B may be due to deregulations in upstream signaling pathways such as Ras/Raf, PI3K/Akt, and NIK. Multiple studies have shown that NF-kappa B is involved in the regulation of apoptosis, angiogenesis, and tumor cell invasion, all of which indicate the important role of NF-kappa B in tumorigenesis. Thus, understanding the molecular mechanism of melanoma progression will aid in designing new therapeutic approaches for melanoma. In this review, the association between NF-kappa B and melanoma tumorigenesis are discussed. Additionally, the potential of emerging selective NF-kappa B inhibitors for the treatment of melanoma is reviewed.

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References

Vucic D, Stennicke H, Pisabarro M, Salvesen G, Dixit V . ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol. 2000; 10(21):1359-66. DOI: 10.1016/s0960-9822(00)00781-8. View

Deng L, Claret F, Kuo M . 2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway. J Biol Chem. 2000; 276(1):413-20. DOI: 10.1074/jbc.M004551200. View

Denkert C, Kobel M, Berger S, SIEGERT A, Leclere A, Trefzer U . Expression of cyclooxygenase 2 in human malignant melanoma. Cancer Res. 2001; 61(1):303-8. View

Yamamoto Y, Gaynor R . Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest. 2001; 107(2):135-42. PMC: 199180. DOI: 10.1172/JCI11914. View

Baldwin A . Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest. 2001; 107(3):241-6. PMC: 199203. DOI: 10.1172/JCI11991. View

Xiao G, Harhaj E, Sun S . NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell. 2001; 7(2):401-9. DOI: 10.1016/s1097-2765(01)00187-3. View

Koul D, Yao Y, Abbruzzese J, Yung W, Reddy S . Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway. J Biol Chem. 2001; 276(14):11402-8. DOI: 10.1074/jbc.M007806200. View

Ravi R, Bedi G, Engstrom L, Zeng Q, Mookerjee B, Gelinas C . Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB. Nat Cell Biol. 2001; 3(4):409-16. DOI: 10.1038/35070096. View

Franco A, Zhang X, Van Berkel E, Sanders J, Zhang X, Thomas W . The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells. J Immunol. 2001; 166(9):5337-45. DOI: 10.4049/jimmunol.166.9.5337. View

10.

Madrid L, Mayo M, Reuther J, Baldwin Jr A . Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem. 2001; 276(22):18934-40. DOI: 10.1074/jbc.M101103200. View

11.

Langley R, Carlisle R, Ma L, Specian R, Gerritsen M, Granger D . Endothelial expression of vascular cell adhesion molecule-1 correlates with metastatic pattern in spontaneous melanoma. Microcirculation. 2001; 8(5):335-45. DOI: 10.1038/sj/mn/7800098. View

12.

Smith C, Andreakos E, Crawley J, Brennan F, Feldmann M, Foxwell B . NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts. J Immunol. 2001; 167(10):5895-903. DOI: 10.4049/jimmunol.167.10.5895. View

13.

Catz S, Johnson J . Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer. Oncogene. 2001; 20(50):7342-51. DOI: 10.1038/sj.onc.1204926. View

14.

McNulty S, Tohidian N, Meyskens Jr F . RelA, p50 and inhibitor of kappa B alpha are elevated in human metastatic melanoma cells and respond aberrantly to ultraviolet light B. Pigment Cell Res. 2002; 14(6):456-65. DOI: 10.1034/j.1600-0749.2001.140606.x. View

15.

Sizemore N, Lerner N, Dombrowski N, Sakurai H, Stark G . Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J Biol Chem. 2001; 277(6):3863-9. DOI: 10.1074/jbc.M110572200. View

16.

Berman K, Verma U, Harburg G, Minna J, Cobb M, Gaynor R . Sulindac enhances tumor necrosis factor-alpha-mediated apoptosis of lung cancer cell lines by inhibition of nuclear factor-kappaB. Clin Cancer Res. 2002; 8(2):354-60. View

17.

Punt C, Eggermont A . Adjuvant interferon-alpha for melanoma revisited: news from old and new studies. Ann Oncol. 2002; 12(12):1663-6. DOI: 10.1023/a:1013592219007. View

18.

Tan C, Waldmann T . Proteasome inhibitor PS-341, a potential therapeutic agent for adult T-cell leukemia. Cancer Res. 2002; 62(4):1083-6. View

19.

Dhawan P, Richmond A . A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells. J Biol Chem. 2002; 277(10):7920-8. PMC: 2668260. DOI: 10.1074/jbc.M112210200. View

20.

Karin M, Lin A . NF-kappaB at the crossroads of life and death. Nat Immunol. 2002; 3(3):221-7. DOI: 10.1038/ni0302-221. View