Differential Contributions of Central and Effector Memory T Cells to Recall Responses

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2005 Jun 29

PMID 15983064

Citations 135

Authors

Alan D Roberts

Kenneth H Ely

David L Woodland

Affiliations

Soon will be listed here.

Abstract

Although the absolute number of memory CD8+ T cells established in the spleen following antigen encounter remains stable for many years, the relative capacity of these cells to mediate recall responses is not known. Here we used a dual adoptive transfer approach to demonstrate a progressive increase in the quality of memory T cell pools in terms of their ability to proliferate and accumulate at effector sites in response to secondary pathogen challenge. This temporal increase in efficacy occurred in CD62L lo (effector memory) and CD62L hi (central memory) subpopulations, but was most prominent in the CD62L hi subpopulation. These data indicate that the contribution of effector memory and central memory T cells to the recall response changes substantially over time.

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