CD8alpha+ Dendritic Cells Selectively Present MHC Class I-restricted Noncytolytic Viral and Intracellular Bacterial Antigens in Vivo

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2005 Jun 24

PMID 15972648

Citations 87

Authors

Gabrielle T Belz

Ken Shortman

Michael J Bevan

William R Heath

Affiliations

Soon will be listed here.

Abstract

CD8alpha(+) dendritic cells (DCs) have been shown to be the principal DC subset involved in priming MHC class I-restricted CTL immunity to a variety of cytolytic viruses, including HSV type 1, influenza, and vaccinia virus. Whether priming of CTLs by CD8alpha(+) DCs is limited to cytolytic viruses, which may provide dead cellular material for this DC subset, or whether these DCs selectively present intracellular Ags, is unknown. To address this question, we examined Ag presentation to a noncytolytic virus, lymphocytic choriomeningitis virus, and to an intracellular bacterium, Listeria monocytogenes. We show that regardless of the type of intracellular infection, CD8alpha(+) DCs are the principal DC subset that initiate CD8(+) T cell immunity.

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