Ocular Cicatricial Pemphigoid: Manifestations and Management

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2005 Jun 22

PMID 15967079

Citations 7

Authors

John H Chang

Peter J McCluskey

Affiliations

Soon will be listed here.

Abstract

Ocular cicatricial pemphigoid (OCP) is a chronic, progressive cicatrizing inflammatory disease of presumed autoimmune etiology affecting the mucous membranes and skin. It has sight-threatening ocular manifestations and potentially life-threatening extraocular manifestations. The ocular signs include: chronic cicatricial conjunctivitis, progressive conjunctival fibrosis, and corneal epitheliopathy. Systemic immunomodulatory therapy is the treatment of choice for controlling disease activity and limiting progression, given the systemic nature of the disease and the poor efficacy of current local or topical therapies. Systemic cyclophosphamide with short-term adjunctive high-dose prednisolone is the preferred treatment for severe and/or rapidly progressing OCP. Oral low-dose weekly methotrexate is a useful first-line treatment for mild-to-moderate OCP. The management of OCP requires a multidisciplinary approach to optimize the care of these patients.

Citing Articles

Challenges and advances in ocular mucous membrane pemphigoid (OMMP); from pathogenesis to treatment strategies.

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Role of immune cells in the ocular manifestations of pemphigoid diseases.

Bose T Ther Adv Ophthalmol. 2019; 11:2515841419868128.

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The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on.

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Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring.

Ahadome S, Abraham D, Rayapureddi S, Saw V, Saban D, Calder V JCI Insight. 2016; 1(12):e87001.

PMID: 27699226 PMC: 5033866. DOI: 10.1172/jci.insight.87001.

Clinical features and in vivo confocal microscopy assessment in 12 patients with ocular cicatricial pemphigoid.

Long Q, Zuo Y, Yang X, Gao T, Liu J, Li Y Int J Ophthalmol. 2016; 9(5):730-7.

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