Expression of CD44v6 Gene in Normal Human Peripheral Blood

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2005 Jun 18

PMID 15962382

Citations 1

Authors

Jian Song

Dong-Sheng Zhang

Jie Zheng

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate if CD44v6 could be used as a molecular marker of cancer progression and metastasis through the detection of CD44v6 gene expression in normal human peripheral blood.

Methods: RNA was extracted from the peripheral blood mononuclear cells of 50 healthy donors, the expression of CD44v6 was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR).

Results: CD44v6 mRNA was detected in 58% of healthy volunteers under the proper controls.

Conclusion: Our results suggest that the measurement of CD44v6 expression in peripheral blood by RT-PCR is not suitable for detection of circulating tumor cells.

Citing Articles

CD44v6 Defines a New Population of Circulating Tumor Cells Not Expressing EpCAM.

Belthier G, Homayed Z, Grillet F, Duperray C, Vendrell J, Krol I Cancers (Basel). 2021; 13(19).

PMID: 34638450 PMC: 8508506. DOI: 10.3390/cancers13194966.

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