[Classification of Wilson's Disease Based on Neurophysiological Parameters]

Overview

Journal Nervenarzt

Specialty Neurology

Date 2005 Jun 17

PMID 15959750

Citations 1

Authors

W Hermann

P Gunther

A Wagner

T Villmann

Affiliations

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Abstract

In addition to hepatolenticular degeneration in Wilson's disease, sensory and extrapyramidal motoric systems are also disturbed. In this study a classification on the basis of neurophysiological parameters (EAEP, VEP, MSEP, TSEP and MEP) was established according to subclinical disturbances of these pathways in patients with Wilson's disease on long-term treatment. A cluster analysis of latencies of these evoked potentials was performed. The results of cluster analysis revealed three types of electrophysiological profiles: type I with normal latencies and types II and III showing different patterns of prolonged latencies. However, there was no correlation between clinical classification and the results of cluster analysis based on the electrophysiological data. The neurophysiological based classification provides additional information about central manifestations and aids in characterizing the progress of the disease.

Citing Articles

[Wilson's disease and Westphal-Strümpell pseudosclerosis: conceptual history in German-speaking countries].

Boide P, Wagner A, Steinberg H Nervenarzt. 2010; 82(10):1335-42.

PMID: 20509019 DOI: 10.1007/s00115-010-3030-8.

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