Model Systems for Flavoenzyme Activity: Site-isolated Redox Behavior in Flavin-functionalized Random Polystyrene Copolymers

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2005 Jun 17

PMID 15957888

Citations 7

Authors

Joseph B Carroll

Brian J Jordan

Hao Xu

Belma Erdogan

Lisa Lee

Lily Cheng

Christopher Tiernan

Graeme Cooke

Vincent M Rotello

Affiliations

Soon will be listed here.

Abstract

[reaction: see text] A model system has been developed to study the redox behaviors of flavin derivatives appended onto random polystyrene copolymers through "click" chemistry strategies. The results demonstrate that flavin units attached onto polymers exhibit site-isolated redox behaviors, yielding new materials with electrochemically tunable associations (K(a)(ox) = 450 M(-)(1), K(a)(red) = 18,200 M(-)(1)) to complementary diamidopyridine (DAP) functionality.

Citing Articles

Directed Electron Transfer in Flavin Peptides with Oligoproline-Type Helical Conformation as Models for Flavin-Functional Proteins.

Worner S, Leier J, Michenfelder N, Unterreiner A, Wagenknecht H ChemistryOpen. 2020; 9(12):1264-1269.

PMID: 33318882 PMC: 7729625. DOI: 10.1002/open.202000199.

Cesium Cation Complexation by a Flavin Receptor via Self-Assembly and Deprotonation.

Oka Y ACS Omega. 2020; 5(33):21226-21230.

PMID: 32875259 PMC: 7450633. DOI: 10.1021/acsomega.0c03006.

Oxidation of alkyl benzenes by a flavin photooxidation catalyst on nanostructured metal-oxide films.

Dongare P, MacKenzie I, Wang D, Nicewicz D, Meyer T Proc Natl Acad Sci U S A. 2017; 114(35):9279-9283.

PMID: 28802257 PMC: 5584444. DOI: 10.1073/pnas.1707318114.

A Click Chemistry Approach towards Flavin-Cyclodextrin Conjugates-Bioinspired Sulfoxidation Catalysts.

Tomanova P, Sturala J, Budesinsky M, Cibulka R Molecules. 2015; 20(11):19837-48.

PMID: 26556319 PMC: 6331787. DOI: 10.3390/molecules201119667.

Catalytic Amine Oxidation under Ambient Aerobic Conditions: Mimicry of Monoamine Oxidase B.

Murray A, Dowley M, Pradaux-Caggiano F, Baldansuren A, Fielding A, Tuna F Angew Chem Int Ed Engl. 2015; 54(31):8997-9000.

PMID: 26087676 PMC: 4524416. DOI: 10.1002/anie.201503654.