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A Benzoisofuranone Derivative and Carbazole Alkaloids from Murraya Koenigii and Their Antimicrobial Activity

Overview
Journal Phytochemistry
Publisher Elsevier
Specialties Biochemistry
Biology
Chemistry
Date 2005 Jun 16
PMID 15955541
Citations 28
Authors
M Mukhlesur Rahman
Alexander I Gray
Affiliations
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Abstract

A benzoisofuranone derivative, 3xi-(1xi-hydroxyethyl)-7-hydroxy-1-isobenzofuranone, and a dimeric carbazole alkaloid, 3,3'-[oxybis(methylene)]bis(9-methoxy-9H-carbazole), along with six known carbazole alkaloids and three known steroids were isolated from the stem bark of Murraya koenigii. The structures of these compounds were established unambiguously by UV, IR, MS and a series of 1D and 2D NMR analyses. The minimum inhibitory concentrations (MIC) of these compounds were found to be in the range 3.13-100 microg/ml.

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