Cytokines and Soluble Interleukin 2 Receptors in Rheumatoid Arthritis

Overview

Journal J Rheumatol

Specialty Rheumatology

Date 1992 Apr 1

PMID 1593571

Citations 3

Authors

R E Wolf

W G Brelsford

V C HALL

S B Adams

Affiliations

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Abstract

Cytokines (IL-1 alpha and IL-2) and soluble interleukin 2 receptors (sIL-2r) were evaluated in patients with rheumatoid arthritis (RA) and controls. In RA, serum sIL-2r and IL-1 alpha were increased, and sIL-2r were significantly higher in synovial fluid than in serum. Serum levels of sIL-1r but not IL-1 alpha were increased in patients with acute infections, suggesting additional discriminatory specificity for IL-1 alpha. Both tender and swollen joint scores were higher for patients with RA with serum sIL-2r levels greater than or equal to 700 U/ml. Quantitation of immune mediators may be useful in the clinical assessment of RA in addition to their implication regarding the pathogenesis of the disease.

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