Immunosuppressive Sesquiterpenes from Tripterygium Wilfordii

Overview

Journal Chem Pharm Bull (Tokyo)

Specialties Chemistry
Pharmacology

Date 2005 Jun 3

PMID 15930767

Citations 5

Authors

Xiaodong Wang

Wenyuan Gao

Zhi Yao

Shaoyu Zhang

Yanwen Zhang

Yoshihisa Takaishi

Hongquan Duan

Affiliations

Soon will be listed here.

Abstract

Five new sesquiterpenes, 1beta-furanoyl-2beta,3alpha,7alpha,8beta,11-pentaacetoxy-4alpha,5alpha-dihydroxy-dihydroagarofuran (1), 1beta,2beta,3alpha,5alpha,7beta,8beta,11-heptaacetoxy-dihydroagarofuran (2), 1beta-furanoyl-2beta,3alpha,7alpha,8beta,11-pentaacetoxy-5alpha-hydroxy-dihydroagarofuran (3), 1beta,7beta,8alpha-triacetoxy-2beta-furanoyl-4alpha-hydroxy-11-isobutyryloxy-dihydroagarofuran (4), and 1beta-nicotinoyl-2beta,5alpha,7beta-triacetoxy-4alpha-hydroxy-11-isobutyryloxy-8alpha-furanoyl-dihydroagarofuran (5), were isolated from the xylem of Tripterygium wilfordii, together with a known compound (6). Their structures were elucidated on the basis of spectroscopic studies. Compounds 2-5 showed significant immunosuppressive activities.

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