Deafness-related Decreases in Glycine-immunoreactive Labeling in the Rat Cochlear Nucleus

Overview

Journal J Neurosci Res

Specialty Neurology

Date 2005 Jun 2

PMID 15929063

Citations 26

Authors

Mikiya Asako

Avril G Holt

Ronald D Griffith

Eric D Buras

Richard A Altschuler

Affiliations

Soon will be listed here.

Abstract

There is increasing evidence of activity-related plasticity in auditory pathways. The present study examined the effects of decreased activity on immunolocalization of the inhibitory neurotransmitter glycine in the cochlear nucleus of the rat after bilateral cochlear ablation. Specifically, glycine-immunoreactive puncta adjacent to somatic profiles were compared in normal hearing animals and animals deafened for 14 days. The number of glycine-immunoreactive puncta surrounding somatic profiles of spherical and globular bushy cells, glycine-immunoreactive type I stellate multipolar cells, radiate neurons (type II stellate multipolar cells), and fusiform cells decreased significantly. In addition, the number of glycine immunopositive tuberculoventral (vertical or corn) cells in the deep layer of the dorsal cochlear nucleus also decreased significantly. These results suggest that decreased inhibition reported in cochlear nucleus after deafness may be due to decreases in glycine.

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