New Pregnane Glycosides from Caralluma Dalzielii

Overview

Journal Steroids

Publisher Elsevier

Specialty Biochemistry

Date 2005 Jun 2

PMID 15927219

Citations 9

Authors

Marinella De Leo

Nunziatina De Tommasi

Rokia Sanogo

Giuseppina Autore

Stefania Marzocco

Cosimo Pizza

Ivano Morelli

Alessandra Braca

Affiliations

Soon will be listed here.

Abstract

Twenty-seven new pregnane glycosides were isolated from the whole plant of Caralluma dalzielii, and their structures elucidated from extensive 2D NMR analysis as well as ESI-MS experiments. All isolated compounds were tested for their antiproliferative activity on J774.A1, HEK-293, and WEHI-164 cell lines. Moderate to high potency of cytotoxicities were found in almost all tested compounds, confirming the significant cytotoxic activity of pregnane glycosides.

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