Evaluation of Autoantibodies to Common and Neuronal Cell Antigens in Chronic Fatigue Syndrome

Overview

Journal J Autoimmune Dis

Publisher Biomed Central

Date 2005 May 27

PMID 15916704

Citations 13

Authors

Suzanne D Vernon

William C Reeves

Affiliations

Soon will be listed here.

Abstract

People with chronic fatigue syndrome (CFS) suffer from multiple symptoms including fatigue, impaired memory and concentration, unrefreshing sleep and musculoskeletal pain. The exact causes of CFS are not known, but the symptom complex resembles that of several diseases that affect the immune system and autoantibodies may provide clues to the various etiologies of CFS. We used ELISA, immunoblot and commercially available assays to test serum from subjects enrolled in a physician-based surveillance study conducted in Atlanta, Georgia and a population-based study in Wichita, Kansas for a number of common autoantibodies and antibodies to neuron specific antigens. Subsets of those with CFS had higher rates of antibodies to microtubule-associated protein 2 (MAP2) (p = 0.03) and ssDNA (p = 0.04). There was no evidence of higher rates for several common nuclear and cellular antigens in people with CFS. Autoantibodies to specific host cell antigens may be a useful approach for identifying subsets of people with CFS, identify biomarkers, and provide clues to CFS etiologies.

Citing Articles

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the biology of a neglected disease.

Arron H, Marsh B, Kell D, Khan M, Jaeger B, Pretorius E Front Immunol. 2024; 15:1386607.

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Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review.

Maksoud R, Magawa C, Eaton-Fitch N, Thapaliya K, Marshall-Gradisnik S BMC Med. 2023; 21(1):189.

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!.

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Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Not Due to Anti-mitochondrial Antibodies.

Nilsson I, Palmer J, Apostolou E, Gottfries C, Rizwan M, Dahle C Front Med (Lausanne). 2020; 7:108.

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Efficacy and safety of Sijunzi Decoction for chronic fatigue syndrome with spleen deficiency pattern: study protocol for a randomized, double-blind, placebo-controlled trial.

Dai L, Zhou W, Wang M, Zhou S, Ji G Ann Transl Med. 2019; 7(20):587.

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