[Neuroendocrine Carcinomas of the Cervix]

Overview

Journal Pathologe

Specialty Pathology

Date 2005 May 26

PMID 15915327

Citations 3

Authors

D Schmidt

L-C Horn

F Kommoss

Affiliations

Soon will be listed here.

Abstract

Neuroendocrine carcinomas of the cervix are rare. They cover a wide age range occurring in young adult women and very old women. Two types are distinguished: small cell carcinoma (oat cell) and large cell neuroendocrine carcinoma. They either occur in pure form or in combination with adenocarcinoma or squamous cell carcinoma. By immunohistochemistry, the expression of at least one neuroendocrine marker (chromogranin, synaptophysin, NSE) is a constant finding. PRb protein can not be detected, whereas the expression of p53 varies. Typically, there is an association with a high risk HPV infection. HPV 18 is found more often than HPV 16. The prognosis is still poor with early metastases to regional lymph nodes and distant sites such as lung, liver, bone, and brain.

Citing Articles

Amphricrine carcinoma of the cervix-adeno neuroendocrine tumor: A case report.

Fadiloglu E, Karalok A, Turkmen O, Asilturk S, Ocalan R, Boran N Turk J Obstet Gynecol. 2017; 13(2):99-102.

PMID: 28913101 PMC: 5558347. DOI: 10.4274/tjod.72325.

[S3 guidelines on diagnostics and treatment of cervical cancer: Demands on pathology].

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Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?.

Halmos G, van der Laan T, van Hemel B, Dikkers F, Slagter-Menkema L, van der Laan B Eur Arch Otorhinolaryngol. 2012; 270(2):719-25.

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