Primary Hyperoxaluria (L-glyceric Aciduria) in a Cat

Overview

Journal J Feline Med Surg

Specialty Veterinary Medicine

Date 2005 May 26

PMID 15914058

Citations 7

Authors

Davide De Lorenzi

Marco Bernardini

Marti Pumarola

Affiliations

Soon will be listed here.

Abstract

A 7-month-old, male European cat was examined because of weakness and inappetence. The cat was dehydrated, polypnoeic and severely weak. Severe, generalised muscle atrophy was present. Spinal reflexes were all decreased to absent. Blood analysis and urinalysis showed several abnormalities, including intermittent hyperoxaluria. The L-gliceric acid concentration was remarkably increased. Electrodiagnostic tests of the peripheral nervous system were abnormal. At necropsy, generalised muscle atrophy was observed. Microscopically, both kidneys showed intraluminal birefringent oxalate crystals. Motor neuron degeneration and accumulation of neurofilaments were observed in the axons of the spinal motor neurons.

Citing Articles

2-Hydroxyglutaric aciduria as a cause for seizure-like episodes in a domestic shorthair cat.

Nye G, Major A, Liebel F JFMS Open Rep. 2019; 5(1):2055116919853898.

PMID: 31245020 PMC: 6582301. DOI: 10.1177/2055116919853898.

Risk factors associated with feline urolithiasis.

Gomes V, Ariza P, Borges N, Schulz Jr F, Fioravanti M Vet Res Commun. 2018; 42(1):87-94.

PMID: 29340849 DOI: 10.1007/s11259-018-9710-8.

Regulation of bone mineral density in the grey squirrel, Sciurus carolinensis: Bioavailability of calcium oxalate, and implications for bark stripping.

Nichols C, Gregory N, Goode N, Gill R, Drewe J J Anim Physiol Anim Nutr (Berl). 2017; 102(1):330-336.

PMID: 28603912 PMC: 5811839. DOI: 10.1111/jpn.12740.

Pathogenesis of calcium oxalate urinary stone disease: species comparison of humans, dogs, and cats.

OKell A, Grant D, Khan S Urolithiasis. 2017; 45(4):329-336.

PMID: 28361470 PMC: 5511574. DOI: 10.1007/s00240-017-0978-x.

Chronic kidney disease with three cases of oxalate-like nephrosis in Ragdoll cats.

Heiene R, Rumsby G, Ziener M, Dahl S, Tims C, Teige J J Feline Med Surg. 2008; 11(6):474-80.

PMID: 19095478 PMC: 10832842. DOI: 10.1016/j.jfms.2008.11.003.

References

Di Tommaso L, Tolomelli B, Mezzini R, Marchetti M, Cenacchi G, Foschini M . Renal calcium phosphate and oxalate deposition in prolonged vitamin B6 deficiency: studies on a rat model of urolithiasis. BJU Int. 2002; 89(6):571-5. DOI: 10.1046/j.1464-410x.2002.02670.x. View

Podell M, Shelton G, Nyhan W, Wagner S, Genders A, Oglesbee M . Methylmalonic and malonic aciduria in a dog with progressive encephalomyelopathy. Metab Brain Dis. 1996; 11(3):239-47. PMC: 7089197. DOI: 10.1007/BF02237961. View

Petrarulo M, Vitale C, Facchini P, Marangella M . Biochemical approach to diagnosis and differentiation of primary hyperoxalurias: an update. J Nephrol. 1998; 11 Suppl 1:23-8. View

Leipold H, Vestweber J, Saperstein G . Spinal muscular atrophy in Brown Swiss calves. Zentralbl Veterinarmed A. 1989; 36(10):731-8. DOI: 10.1111/j.1439-0442.1989.tb00786.x. View

SHIELDS R, Vandevelde M . Spontaneous lower motor neuron disease in rabbits (oryctolagus cuniculus). Acta Neuropathol. 1978; 44(2):85-90. DOI: 10.1007/BF00691473. View

Shelton G, Hopkins A, Ginn P, de Lahunta A, Cummings J, Berryman F . Adult-onset motor neuron disease in three cats. J Am Vet Med Assoc. 1998; 212(8):1271-5. View

Sewell A, Moritz A, Duran M . D-(+)-glyceric aciduria in an Afghan hound. J Inherit Metab Dis. 1997; 20(3):395-6. DOI: 10.1023/a:1005346532138. View

Jansen J, Arnesen K . Oxalate nephropathy in a Tibetan spaniel litter. A probable case of primary hyperoxaluria. J Comp Pathol. 1990; 103(1):79-84. DOI: 10.1016/s0021-9975(08)80137-5. View

Vandevelde M, Greene C, HOFF E . Lower motor neuron disease with accumulation of neurofilaments in a cat. Vet Pathol. 1976; 13(6):428-35. DOI: 10.1177/030098587601300604. View

10.

Dickie C, Hamann M, Carroll W, Chow F . Oxalate (Rumex venosus) poisoning in cattle. J Am Vet Med Assoc. 1978; 173(1):73-4. View

11.

Kramek B, Moise N, Cooper B, Raffe M . Neuropathy associated with diabetes mellitus in the cat. J Am Vet Med Assoc. 1984; 184(1):42-5. View

12.

Hubler M, Haskins M, Arnold S, Kaser-Hotz B, Bosshard N, Briner J . Mucolipidosis type II in a domestic shorthair cat. J Small Anim Pract. 1996; 37(9):435-41. DOI: 10.1111/j.1748-5827.1996.tb02444.x. View

13.

Jones B, Johnstone A, Cahill J, Hancock W . Peripheral neuropathy in cats with inherited primary hyperchylomicronaemia. Vet Rec. 1986; 119(11):268-72. DOI: 10.1136/vr.119.11.268. View

14.

Rousseaux C, Klavano G, Johnson E, Shnitka T, Harries W, SNYDER F . "Shaker" calf syndrome: a newly recognized inherited neurodegenerative disorder of horned Hereford calves. Vet Pathol. 1985; 22(2):104-11. DOI: 10.1177/030098588502200202. View

15.

Cork L, Price D, Griffin J, Sack Jr G . Hereditary canine spinal muscular atrophy: canine motor neuron disease. Can J Vet Res. 1990; 54(1):77-82. PMC: 1255609. View

16.

Thrall M, Grauer G, Mero K . Clinicopathologic findings in dogs and cats with ethylene glycol intoxication. J Am Vet Med Assoc. 1984; 184(1):37-41. View

17.

McKerrell R, Blakemore W, Heath M, Plumb J, Bennett M, Pollitt R . Primary hyperoxaluria (L-glyceric aciduria) in the cat: a newly recognised inherited disease. Vet Rec. 1989; 125(2):31-4. DOI: 10.1136/vr.125.2.31. View

18.

Morgan L, McConnell J . Cobalamin deficiency associated with erythroblastic anemia and methylmalonic aciduria in a border collie. J Am Anim Hosp Assoc. 1999; 35(5):392-5. DOI: 10.5326/15473317-35-5-392. View

19.

Shell L, Jortner B, Leib M . Spinal muscular atrophy in two Rottweiler littermates. J Am Vet Med Assoc. 1987; 190(7):878-80. View

20.

Agerholm J, Basse A . Spinal muscular atrophy in calves of the Red Danish dairy breed. Vet Rec. 1994; 134(10):232-5. DOI: 10.1136/vr.134.10.232. View