Changes in the Coagulation-fibrinolysis Balance of Endothelial Cells and Mononuclear Phagocytes: Role in Disseminated Intravascular Coagulation Associated with Infectious Diseases

Overview

Journal Int J Clin Lab Res

Specialties Biochemistry
General Medicine

Date 1992 Jan 1

PMID 1591371

Citations 4

Authors

N Semeraro

M Colucci

Affiliations

Soon will be listed here.

Abstract

Over the last few years, evidence has accumulated that the pathogenetic mechanism of disseminated intravascular coagulation encountered in patients with infectious diseases is extraordinarily complex and involves multiple interactions between the microorganism itself and/or a number of mediators, both microorganism derived and host manufactured, and multifunctional cellular systems, namely endothelial cells and mononuclear phagocytes. In particular, infectious agents and mediators shift the coagulation-fibrinolysis equilibrium of these cells towards fibrin formation and accumulation, via enhancement of procoagulant properties and reduction of both anticoagulant and fibrinolytic capacities. New insights into the pathogenetic mechanism may have important implications for the management of infected patients with disseminated intravascular coagulation.

Citing Articles

Statins and Hemostasis: Therapeutic Potential Based on Clinical Evidence.

Prado Y, Aravena D, Llancalahuen F, Aravena C, Eltit F, Echeverria C Adv Exp Med Biol. 2023; 1408:25-47.

PMID: 37093420 DOI: 10.1007/978-3-031-26163-3_2.

Indoor nanoscale particulate matter-induced coagulation abnormality based on a human 3D microvascular model on a microfluidic chip.

Li Y, Hu C, Wang P, Liu Y, Wang L, Pi Q J Nanobiotechnology. 2019; 17(1):20.

PMID: 30709410 PMC: 6357445. DOI: 10.1186/s12951-019-0458-2.

Sepsis-associated disseminated intravascular coagulation and thromboembolic disease.

Semeraro N, Ammollo C, Semeraro F, Colucci M Mediterr J Hematol Infect Dis. 2011; 2(3):e2010024.

PMID: 21415977 PMC: 3033145. DOI: 10.4084/MJHID.2010.024.

Disseminated intravascular coagulation associated with disseminated cryptococcosis in a patient with acquired immunodeficiency syndrome.

Fera G, Semeraro N, De Mitrio V, SCHIRALDI O Infection. 1993; 21(3):171-3.

PMID: 8365814 DOI: 10.1007/BF01710541.

References

Edwards R, Rickles F . Macrophage procoagulants. Prog Hemost Thromb. 1984; 7:183-209. View

Conkling P, Chua C, Nadler P, Greenberg C, Doty E, Misukonis M . Clinical trials with human tumor necrosis factor: in vivo and in vitro effects on human mononuclear phagocyte function. Cancer Res. 1988; 48(19):5604-9. View

Idell S, James K, Levin E, Schwartz B, Manchanda N, Maunder R . Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989; 84(2):695-705. PMC: 548934. DOI: 10.1172/JCI114217. View

Kobayashi M, Shimada K, Ozawa T . Human recombinant interleukin-1 beta- and tumor necrosis factor alpha-mediated suppression of heparin-like compounds on cultured porcine aortic endothelial cells. J Cell Physiol. 1990; 144(3):383-90. DOI: 10.1002/jcp.1041440304. View

Levy G, Abecassis M . Activation of the immune coagulation system by murine hepatitis virus strain 3. Rev Infect Dis. 1989; 11 Suppl 4:S712-21. PMC: 7792906. DOI: 10.1093/clinids/11.supplement_4.s712. View

Chapman Jr H, Vavrin Z, Hibbs Jr J . Coordinate expression of macrophage procoagulant and fibrinolytic activity in vitro and in vivo. J Immunol. 1983; 130(1):261-6. View

Paramo J, Perez J, Serrano M, Rocha E . Types 1 and 2 plasminogen activator inhibitor and tumor necrosis factor alpha in patients with sepsis. Thromb Haemost. 1990; 64(1):3-6. View

Castellote J, Grau E, Linde M, Pujol-Moix N, Rutllant M . Detection of both type 1 and type 2 plasminogen activator inhibitors in human monocytes. Thromb Haemost. 1990; 63(1):67-71. View

Bevilacqua M, Pober J, Majeau G, Fiers W, COTRAN R, Gimbrone Jr M . Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1. Proc Natl Acad Sci U S A. 1986; 83(12):4533-7. PMC: 323768. DOI: 10.1073/pnas.83.12.4533. View

10.

Sawdey M, Podor T, Loskutoff D . Regulation of type 1 plasminogen activator inhibitor gene expression in cultured bovine aortic endothelial cells. Induction by transforming growth factor-beta, lipopolysaccharide, and tumor necrosis factor-alpha. J Biol Chem. 1989; 264(18):10396-401. View

11.

Colucci M, Balconi G, Lorenzet R, Pietra A, Locati D, Donati M . Cultured human endothelial cells generate tissue factor in response to endotoxin. J Clin Invest. 1983; 71(6):1893-6. PMC: 370395. DOI: 10.1172/jci110945. View

12.

Brukman J, Wiggins R . Procoagulant activity in kidneys of normal and bacterial lipopolysaccharide-treated rabbits. Kidney Int. 1987; 32(1):31-8. DOI: 10.1038/ki.1987.168. View

13.

Wohlwend A, Belin D, Vassalli J . Plasminogen activator-specific inhibitors produced by human monocytes/macrophages. J Exp Med. 1987; 165(2):320-39. PMC: 2188521. DOI: 10.1084/jem.165.2.320. View

14.

Colucci M, Altomare D, Chetta G, Triggiani R, Cavallo L, Semeraro N . Impaired fibrinolysis in obstructive jaundice--evidence from clinical and experimental studies. Thromb Haemost. 1988; 60(1):25-9. View

15.

Colucci M, Paramo J, Stassen J, Collen D . Influence of the fast-acting inhibitor of plasminogen activator on in vivo thrombolysis induced by tissue-type plasminogen activator in rabbits. Interference of tissue-derived components. J Clin Invest. 1986; 78(1):138-44. PMC: 329542. DOI: 10.1172/JCI112543. View

16.

STERN D, Kaiser E, Nawroth P . Regulation of the coagulation system by vascular endothelial cells. Haemostasis. 1988; 18(4-6):202-14. DOI: 10.1159/000215808. View

17.

Wilcox J, Smith K, Schwartz S, Gordon D . Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci U S A. 1989; 86(8):2839-43. PMC: 287014. DOI: 10.1073/pnas.86.8.2839. View

18.

Ogawa S, Gerlach H, Esposito C, Brett J, Stern D . Hypoxia modulates the barrier and coagulant function of cultured bovine endothelium. Increased monolayer permeability and induction of procoagulant properties. J Clin Invest. 1990; 85(4):1090-8. PMC: 296539. DOI: 10.1172/JCI114540. View

19.

Vercellotti G . Proinflammatory and procoagulant effects of herpes simplex infection on human endothelium. Blood Cells. 1990; 16(1):209-15; discussion 215-6. View

20.

Suffredini A, HARPEL P, Parrillo J . Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects. N Engl J Med. 1989; 320(18):1165-72. DOI: 10.1056/NEJM198905043201802. View