Asperger Syndrome: Familial and Pre- and Perinatal Factors

Overview

Journal J Autism Dev Disord

Publisher Springer

Date 2005 May 25

PMID 15909402

Citations 17

Authors

Christopher Gillberg

Mats Cederlund

Affiliations

Soon will be listed here.

Abstract

Objective: Study familial and pre- and perinatal factors in Asperger Syndrome (AS).

Methods: One hundred boys with AS had their records reviewed. "Pathogenetic subgroups" were defined according to presence of medical syndromes/chromosomal abnormalities, indices of familiality, and pre- and perinatal risk factors predisposing to brain damage.

Results: No major index of pathogenetic factors was found in 13%, a syndrome/chromosomal abnormality in 8%, pre- or perinatal risk 13%, combined pre- or perinatal risk and family history in 11%, and family history only in 55%.

Comment: About 50% of all boys with AS have a paternal family history of autism spectrum disorder. Pre- and perinatal risks appear to be important in about 25% of cases.

Citing Articles

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Empathy in Autism Spectrum Disorder.

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Asperger syndrome in childhood - personality dimensions in adult life: temperament, character and outcome trajectories.

Helles A, Wallinius M, Gillberg I, Gillberg C, Billstedt E BJPsych Open. 2016; 2(3):210-216.

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3p22.1p21.31 microdeletion identifies CCK as Asperger syndrome candidate gene and shows the way for therapeutic strategies in chromosome imbalances.

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