» Articles » PMID: 15907150

Social Anxiety Disorder : Current Treatment Recommendations

Overview
Journal CNS Drugs
Specialties Neurology
Pharmacology
Date 2005 May 24
PMID 15907150
Citations 5
Authors
Affiliations
Soon will be listed here.
Abstract

Social anxiety disorder (SAD) is a prevalent and disabling disorder associated with significant co-morbidity. An increased awareness of SAD over the past two decades has given impetus to advances in the pharmacotherapeutic and psychotherapeutic treatment options for this disorder. On the basis of consistent data from randomised controlled trials, present consensus supports the use of SSRIs as the first-line treatment in generalised SAD, partly because of established short- and long-term efficacy in this disorder, evidence for safety and tolerability, and ability to treat co-morbid conditions. There is more recent evidence that venlafaxine XR (extended release) may also be considered a first-line treatment in SAD. Second-line treatments include MAOIs (e.g. phenelzine) and reversible inhibitors of monoamine oxidase A (e.g. moclobemide), while some benzodiazepines and antiepileptics (e.g. clonazepam and pregabalin) may also be useful. Over the past two decades, cognitive behavioural therapies for SAD have gained increasing empirical support. The optimal approach to the management of treatment-refractory SAD patients requires additional study.

Citing Articles

Limbic oxytocin receptor expression alters molecular signaling and social avoidance behavior in female prairie voles ().

Nerio-Morales L, Boender A, Young L, Lamprea M, Smith A Front Neurosci. 2024; 18:1409316.

PMID: 39081850 PMC: 11286410. DOI: 10.3389/fnins.2024.1409316.


The Efficacy of Augment of D-Cycloserine and Cognitive-behavioral Therapy on Adolescent with one Type of Anxiety Disorders: A Double-blind Randomized Controlled Trial.

Arman S, Soheilimehr A, Maracy M Adv Biomed Res. 2017; 6:11.

PMID: 28299303 PMC: 5343611. DOI: 10.4103/2277-9175.200786.


The noradrenergic action in antidepressant treatments: pharmacological and clinical aspects.

DellOsso B, Palazzo M, Oldani L, Altamura A CNS Neurosci Ther. 2010; 17(6):723-32.

PMID: 21155988 PMC: 6493872. DOI: 10.1111/j.1755-5949.2010.00217.x.


A 2010 evidence-based algorithm for the pharmacotherapy of social anxiety disorder.

Stein D, Baldwin D, Bandelow B, Blanco C, Fontenelle L, Lee S Curr Psychiatry Rep. 2010; 12(5):471-7.

PMID: 20686872 DOI: 10.1007/s11920-010-0140-8.


Efficacy and tolerability of second-generation antidepressants in social anxiety disorder.

Hansen R, Gaynes B, Gartlehner G, Moore C, Tiwari R, Lohr K Int Clin Psychopharmacol. 2008; 23(3):170-9.

PMID: 18408531 PMC: 2657552. DOI: 10.1097/YIC.0b013e3282f4224a.

References
1.
Emmanuel N, MORTON W, Book S, Johnson M, Lorberbaum J, Ballenger J . Bupropion-SR in treatment of social phobia. Depress Anxiety. 2000; 12(2):111-3. DOI: 10.1002/1520-6394(2000)12:2<111::AID-DA9>3.0.CO;2-3. View

2.
Naranjo C, Knoke D . The role of selective serotonin reuptake inhibitors in reducing alcohol consumption. J Clin Psychiatry. 2001; 62 Suppl 20:18-25. View

3.
Ballenger J . Treatment of anxiety disorders to remission. J Clin Psychiatry. 2001; 62 Suppl 12:5-9. View

4.
Davidson J, Foa E, Huppert J, Keefe F, Franklin M, Compton J . Fluoxetine, comprehensive cognitive behavioral therapy, and placebo in generalized social phobia. Arch Gen Psychiatry. 2004; 61(10):1005-13. DOI: 10.1001/archpsyc.61.10.1005. View

5.
Versiani M, Mundim F, Nardi A, Liebowitz M . Tranylcypromine in social phobia. J Clin Psychopharmacol. 1988; 8(4):279-83. View