» Articles » PMID: 15904927

Histopathological Studies of Experimental Lyme Disease in the Dog

Overview
Journal J Comp Pathol
Publisher Elsevier
Date 2005 May 21
PMID 15904927
Citations 30
Authors
Affiliations
Soon will be listed here.
Abstract

Experimental borrelia infection was induced in 62 specific--pathogen-free beagle dogs by exposure to Ixodes scapularis ticks harbouring the spirochaete Borrelia burgdorferi. Clinical signs of Lyme disease occurred in 39/62 dogs, the remaining 23 being subclinically infected. Clinical signs consisted of one to six episodes of transitory lameness with joint swelling and pain, most commonly affecting the elbow or shoulder joints. The polymerase chain reaction and culture demonstrated that the dogs remained infected for up to 581 days. At necropsy, gross findings consisted of lymphadenopathy in the area of tick attachment. Microscopical changes consisted of effusive fibrinosuppurative inflammation or nonsuppurative inflammation, or both, affecting synovial membranes, joint capsules and associated tendon sheaths. Plasma cells dominated areas of chronic inflammation, with CD3(+) T cells being present in lesser numbers. Microscopical signs of arthritis were polyarticular and more widespread than indicated by clinical signs, and most of the subclinically affected animals also had synovitis. In areas of tick attachment to the skin, hyperkeratosis and a mixture of suppurative and nonsuppurative dermatitis were encountered. Lymphadenopathy in superficial lymph nodes resulted from follicular and parafollicular hyperplasia. In 14/62 dogs, lymphoplasmacytic periarteritis and perineuritis were noted, resembling lesions found in human Lyme disease and syphilis, in which an underlying microangiopathy has been proposed.

Citing Articles

Novel recombinant vaccinia virus-vectored vaccine affords complete protection against homologous infection in mice.

Pfeifle A, Zhang W, Cao J, Thulasi Raman S, Anderson-Duvall R, Tamming L Emerg Microbes Infect. 2024; 13(1):2399949.

PMID: 39221484 PMC: 11486199. DOI: 10.1080/22221751.2024.2399949.


DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous needle challenge in mice.

Pfeifle A, Thulasi Raman S, Lansdell C, Zhang W, Tamming L, Cecillon J Front Immunol. 2023; 14:1020134.

PMID: 37006299 PMC: 10060826. DOI: 10.3389/fimmu.2023.1020134.


Is Sensu Stricto in South America? First Molecular Evidence of Its Presence in Colombia.

Mancilla-Agrono L, Banguero-Micolta L, Ossa-Lopez P, Ramirez-Chaves H, Castano-Villa G, Rivera-Paez F Trop Med Infect Dis. 2022; 7(12).

PMID: 36548683 PMC: 9788524. DOI: 10.3390/tropicalmed7120428.


Detection of Sensu-Lato-Specific Antibodies in Sera of Canine and Equine Origin-A Comparative Study with Two Line Immunoassays.

Doff S, Wenderlein J, Wiesinger A, Hiereth S, Ulrich S, Straubinger R Vet Sci. 2022; 9(11).

PMID: 36423082 PMC: 9695075. DOI: 10.3390/vetsci9110633.


Persistent Borrelia burgdorferi Infection after Antibiotic Treatment: Systematic Overview and Appraisal of the Current Evidence from Experimental Animal Models.

Verschoor Y, Vrijlandt A, Spijker R, van Hest R, Ter Hofstede H, van Kempen K Clin Microbiol Rev. 2022; 35(4):e0007422.

PMID: 36222707 PMC: 9769629. DOI: 10.1128/cmr.00074-22.