Analysis of the Melon Genome in Regions Encompassing TIR-NBS-LRR Resistance Genes

Overview

Journal Mol Genet Genomics

Specialty Genetics

Date 2005 May 20

PMID 15902490

Citations 18

Authors

Hans van Leeuwen

Jordi Garcia-Mas

Maria Coca

Pere Puigdomenech

Amparo Monfort

Affiliations

Soon will be listed here.

Abstract

Plant genomes contain numerous genes (R-genes) that play a role in initiating defence measures against their particular pathogens. Defence mechanisms controlled by R-genes have been the focus of extensive research over the past several years. The majority of the R-genes described so far belong to a super-family of genes (150-600 members) that encode proteins with a nucleotide binding site (NBS), some leucine-rich repeats (LRR) and an N-terminal domain that shows similarity to the Toll and Interleukin-1 receptors (TIR) or a N-terminal coiled-coil (CC) domain. Analysis of four regions of the melon (Cucumis melo) genome, including two sequenced BACs, identified 14 TIR-NBS-LRR genes. Known disease resistance genes have been mapped in three of these regions. Transcriptional expression was detected for predicted genes that are possibly involved in defence responses to pathogen attack. TIR-NBS-LRR genes appear to be clustered in the melon genome. They contain all the conserved motifs that have previously been described for their counterparts in other species, although differences were also detected. The results presented here may contribute to a better understanding of the genomic distribution and evolution of this group of resistance gene homologues and their variability.

Citing Articles

Pan-Genome Analysis Reveals the Abundant Gene Presence/Absence Variations Among Different Varieties of Melon and Their Influence on Traits.

Sun Y, Wang J, Li Y, Jiang B, Wang X, Xu W Front Plant Sci. 2022; 13:835496.

PMID: 35401600 PMC: 8990847. DOI: 10.3389/fpls.2022.835496.

Characterization, identification and expression profiling of genome-wide R-genes in melon and their putative roles in bacterial fruit blotch resistance.

Islam M, Hossain M, Jesse D, Jung H, Kim H, Park J BMC Genet. 2020; 21(1):80.

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Development of Molecular Marker Linked with Bacterial Fruit Blotch Resistance in Melon ( L.).

Islam M, Hossain M, Jesse D, Jung H, Kim H, Park J Genes (Basel). 2020; 11(2).

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Variability among Cucurbitaceae species (melon, cucumber and watermelon) in a genomic region containing a cluster of NBS-LRR genes.

Morata J, Puigdomenech P BMC Genomics. 2017; 18(1):138.

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Interspecific and intraspecific gene variability in a 1-Mb region containing the highest density of NBS-LRR genes found in the melon genome.

Gonzalez V, Aventin N, Centeno E, Puigdomenech P BMC Genomics. 2014; 15:1131.

PMID: 25523007 PMC: 4378003. DOI: 10.1186/1471-2164-15-1131.

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