Cell Type-specific Genotoxic Effects of Intermittent Extremely Low-frequency Electromagnetic Fields

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 2005 May 19

PMID 15899587

Citations 21

Authors

Sabine Ivancsits

Alexander Pilger

Elisabeth Diem

Oswald Jahn

Hugo W Rudiger

Affiliations

Soon will be listed here.

Abstract

The issue of adverse health effects of extremely low-frequency electromagnetic fields (ELF-EMFs) is highly controversial. Contradictory results regarding the genotoxic potential of ELF-EMF have been reported in the literature. To test whether this controversy might reflect differences between the cellular targets examined we exposed cultured cells derived from different tissues to an intermittent ELF-EMF (50 Hz sinusoidal, 1 mT) for 1-24h. The alkaline and neutral comet assays were used to assess ELF-EMF-induced DNA strand breaks. We could identify three responder (human fibroblasts, human melanocytes, rat granulosa cells) and three non-responder cell types (human lymphocytes, human monocytes, human skeletal muscle cells), which points to the significance of the cell system used when investigating genotoxic effects of ELF-EMF.

Citing Articles

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System-level biological effects of extremely low-frequency electromagnetic fields: an experimental review.

Tian H, Zhu H, Gao C, Shi M, Yang D, Jin M Front Neurosci. 2023; 17:1247021.

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Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios.

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A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial.

Okano H, Fujimura A, Kondo T, Laakso I, Ishiwatari H, Watanuki K PLoS One. 2021; 16(8):e0255242.

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