Activation of C-Jun N-terminal Kinase (JNK) Pathway by HSV-1 Immediate Early Protein ICP0

Overview

Journal Exp Cell Res

Specialty Cell Biology

Date 2005 May 18

PMID 15896775

Citations 21

Authors

Lirong Diao

Bianhong Zhang

Chenghao Xuan

Shaogang Sun

Kai Yang

Yujie Tang

Wentao Qiao

Qimin Chen

Yunqi Geng

Chen Wang

Affiliations

Soon will be listed here.

Abstract

The immediate early protein ICP0 encoded by herpes simplex virus 1 (HSV-1) is believed to activate transcription and consequently productive infection. The precise mechanisms of ICP0-mediated transactivation are under intensive study. Here, we demonstrate that ICP0 can strongly activate AP-1 responsive genes specifically. This activation is inhibited by c-Jun (S73A), c-Jun (S63/73A), TAK1 (K63W), but not by p38 (AF), ERK1 (K71R), ERK2 (K52R) and TRAF6 (C85A/H87A). We further investigate the relevancy of ERK, JNK and p38 MAPK pathways using their respective inhibitors PD98059, SP600125 and SB202190. Only SP600125 significantly attenuates the AP-1 responsive gene activation by ICP0. Consistent with these, the JNK is remarkably activated in response to ICP0, and this JNK activation is shown to be significantly attenuated by TAK1 (K63W). It turns out that ICP0 interacts specifically with TAK1 and stimulates its kinase activity. These findings reveal a new molecular mechanism ICP0 explores to regulate gene expression.

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