Single-dose Contrast Agent for Intraoperative MR Imaging of Intrinsic Brain Tumors by Using Ferumoxtran-10

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2005 May 14

PMID 15891164

Citations 14

Authors

Matthew A Hunt

Attila G Bago

Edward A Neuwelt

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Intraoperative MR imaging (IMRI) has advantages over conventional framed and frameless techniques. IMRI, however, also has some drawbacks, especially related to interpretation of gadolinium-enhanced intraoperative imaging resulting from surgically induced blood brain barrier injury, vascular changes, and hemorrhage. Ultra-small superparamagnetic iron particles like ferumoxtran-10 have a long plasma half-life and are trapped by reactive cells within the tumor. These trapped particles provide a method to demonstrate enhancing lesions without the artifact of repeat gadolinium administration in the face of blood brain barrier and vascular injury.

Methods: We present a review of the literature and the cases of two patients who underwent surgery in which IMRI with ferumoxtran-10 was used.

Results: Ultra-small superparamagnetic iron particles represent a method to demonstrate enhancing intrinsic brain tumors without the drawbacks of intraoperative gadolinium enhancement. These lesions appear even on low-field strength IMRI. Ferumoxtran-10, administered preoperatively, provides a stable imaging marker, even after surgical manipulation of the brain.

Conclusion: Fermumoxtran-10 provides a way to lessen artifactual enhancement during IMRI related to the administration of gadolinium.

Citing Articles

Ferumoxytol-Enhanced MRI in Children and Young Adults: State of the Art.

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PMID: 36197052 PMC: 10038879. DOI: 10.2214/AJR.22.28453.

Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle.

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Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide.

Alam S, Stirrat C, Richards J, Mirsadraee S, Semple S, Tse G J Cardiovasc Magn Reson. 2015; 17:83.

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The Art of Intraoperative Glioma Identification.

Zhang Z, Shields L, Sun D, Zhang Y, Hunt M, Shields C Front Oncol. 2015; 5:175.

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Nanoparticle enhanced MRI scanning to detect cellular inflammation in experimental chronic renal allograft rejection.

Alam S, Tse G, Stirrat C, MacGillivray T, Lennen R, Jansen M Int J Mol Imaging. 2015; 2015:507909.

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