Effects of Chronic Lead Exposure on 1H MRS of Hippocampus and Frontal Lobes in Children

Overview

Journal Neurology

Specialty Neurology

Date 2005 May 11

PMID 15883337

Citations 15

Authors

X-M Meng

D-M Zhu

D-Y Ruan

J-Q She

L Luo

Affiliations

Soon will be listed here.

Abstract

The authors performed IQ testing and magnetic resonance spectroscopy on six lead-exposed and six control children. Levels of N-acetyl aspartate (neuronal density and mitochondrial metabolism), creatine + phosphocreatine (phosphate metabolism), and choline (membrane turnover) were decreased in four brain regions (left and right frontal, left and right hippocampus) in lead-exposed children vs controls. The reductions were right frontal > left frontal > hippocampus but were the same bilaterally in the hippocampus.

Citing Articles

Vulnerability of the Hippocampus to Insults: Links to Blood-Brain Barrier Dysfunction.

Davidson T, Stevenson R Int J Mol Sci. 2024; 25(4).

PMID: 38396670 PMC: 10888241. DOI: 10.3390/ijms25041991.

Topological network properties of resting-state functional connectivity patterns are associated with metal mixture exposure in adolescents.

Invernizzi A, Rechtman E, Oluyemi K, Renzetti S, Curtin P, Colicino E Front Neurosci. 2023; 17:1098441.

PMID: 36814793 PMC: 9939635. DOI: 10.3389/fnins.2023.1098441.

Toxicant exposure and the developing brain: A systematic review of the structural and functional MRI literature.

Fowler C, Bagdasarov A, Camacho N, Reuben A, Gaffrey M Neurosci Biobehav Rev. 2022; 144:105006.

PMID: 36535373 PMC: 9922521. DOI: 10.1016/j.neubiorev.2022.105006.

Cognitive Impairment Induced by Lead Exposure during Lifespan: Mechanisms of Lead Neurotoxicity.

Ramirez Ortega D, Gonzalez Esquivel D, Blanco Ayala T, Pineda B, Gomez Manzo S, Marcial Quino J Toxics. 2021; 9(2).

PMID: 33525464 PMC: 7912619. DOI: 10.3390/toxics9020023.

Olive leaf extract inhibits lead poisoning-induced brain injury.

Wang Y, Wang S, Cui W, He J, Wang Z, Yang X Neural Regen Res. 2014; 8(22):2021-9.

PMID: 25206510 PMC: 4146066. DOI: 10.3969/j.issn.1673-5374.2013.22.001.