Dampened Ventilatory Response to Added Dead Space in Newborns of Smoking Mothers

Overview

Journal Arch Dis Child Fetal Neonatal Ed

Specialties Gynecology & Obstetrics
Pediatrics

Date 2005 May 10

PMID 15878936

Citations 4

Authors

R Y Bhat

S Broughton

B Khetriwal

G F Rafferty

S Hannam

A D Milner

A Greenough

Affiliations

Soon will be listed here.

Abstract

Background: Term newborns can compensate fully for an imposed dead space (tube breathing) by increasing their minute ventilation.

Objective: To test the hypothesis that infants of smoking mothers would have an impaired response to tube breathing.

Design: Prospective study.

Setting: Perinatal service.

Patients: Fourteen infants of smoking and 24 infants of non-smoking mothers (median postnatal age 37 (11-85) hours and 26 (10-120) hours respectively) were studied.

Interventions: Breath by breath minute volume was measured at baseline and when a dead space of 4.4 ml/kg was incorporated into the breathing circuit.

Main Outcome Measures: The maximum minute ventilation during tube breathing was determined and the time constant of the response calculated.

Results: The time constant of the infants of smoking mothers was longer than that of the infants of non-smoking mothers (median (range) 37.3 (22.2-70.2) v 26.2 (13.8-51.0) seconds, p = 0.016). Regression analysis showed that maternal smoking status was related to the time constant independently of birth weight, gestational or postnatal age, or sex (p = 0.018).

Conclusions: Intrauterine exposure to smoking is associated with a dampened response to tube breathing.

Citing Articles

Ventilatory response to added dead space in infants exposed to second-hand smoke in pregnancy.

Jenkinson A, Bednarczuk N, Kaltsogianni O, Williams E, Lee R, Bhat R Eur J Pediatr. 2023; 182(7):3301-3306.

PMID: 37166537 PMC: 10354125. DOI: 10.1007/s00431-023-04991-5.

Acute Prenatal Hypoxia in Rats Affects Physiology and Brain Metabolism in the Offspring, Dependent on Sex and Gestational Age.

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Environmental Pollution and the Developing Lung.

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The effect of caffeine on the ventilatory response to hypercarbia in preterm infants.

Rossor T, Bhat R, Ali K, Peacock J, Rafferty G, Greenough A Pediatr Res. 2018; 83(6):1152-1157.

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