A Double Mutation in the GyrA Gene is Necessary to Produce High Levels of Resistance to Moxifloxacin in Campylobacter Spp. Clinical Isolates

Overview

Journal Int J Antimicrob Agents

Specialties Infectious Diseases
Pharmacology

Date 2005 May 7

PMID 15876526

Citations 7

Authors

Joaquim Ruiz

Asuncion Moreno

M Teresa Jimenez de Anta

Jordi Vila

Affiliations

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Abstract

The aim of this study was to compare different fluoroquinolones against Campylobacter spp., analysing the molecular mechanisms of resistance. Moxifloxacin exhibited the greatest activity of the quinolones tested, being active against isolates carrying a single mutation in the gyrA gene. High resistance levels to moxifloxacin were related to the presence of a double gyrA mutation.

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