Human Immunodeficiency Virus Type 1 Enhances Intracellular Growth of Mycobacterium Avium in Human Macrophages

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1992 Jun 1

PMID 1587613

Citations 7

Authors

G Kallenius

T Koivula

K J Rydgard

S E Hoffner

A Valentin

B Asjo

C Ljungh

U Sharma

S B Svenson

Affiliations

Soon will be listed here.

Abstract

Disseminated Mycobacterium avium infections are common in patients with AIDS and result in a reduced life expectancy. Human monocytes/macrophages are important target cells for both human immunodeficiency virus (HIV) and M. avium. We have studied the interaction in vitro of M. avium and HIV type 1 (HIV-1) in human macrophages. Human monocytes isolated from the peripheral blood of healthy individuals were infected with HIV-1, M. avium, or both. The intracellular growth of M. avium and the replication of HIV-1 were monitored for up to 5 weeks. Intracellular mycobacterial growth was seen in all M. avium infected cell cultures and was paralleled by increased production of interleukin 1 alpha and beta. Preinfection of the macrophages with HIV-1 reduced the interleukin 1 production and accelerated the intracellular growth of M. avium. These findings may explain in part the impaired control of mycobacterial infections seen with patients with AIDS.

Citing Articles

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The Mycobacterium avium complex.

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