Direct Electrochemical Regeneration of Monooxygenase Subunits for Biocatalytic Asymmetric Epoxidation

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2005 May 5

PMID 15869268

Citations 16

Authors

Frank Hollmann

Karin Hofstetter

Tilo Habicher

Bernhard Hauer

Andreas Schmid

Affiliations

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Abstract

We report the first example of direct electrochemical regeneration of a flavin-dependent monooxygenase for asymmetric epoxidation catalysis. It is shown that electrochemical regeneration of the oxygenase subunit of the multicomponent styrene monooxygenase is sufficient to perform enantiospecific S-epoxidation of various styrene derivatives. Kinetic bottlenecks of the novel electroenzymatic reaction are identified. This work opens up new alternatives for asymmetric oxyfunctionalization catalysis.

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