Involvement of Proinflammatory Cytokines IL-1beta and IL-6 in Progression of Human Gastric Carcinoma

Overview

Journal Anticancer Res

Specialty Oncology

Date 2005 May 5

PMID 15868900

Citations 49

Authors

Hirohisa Kai

Yasuhiko Kitadai

Michiyo Kodama

Songde Cho

Tsuyoshi Kuroda

Masanori Ito

Shinji Tanaka

Yasukazu Ohmoto

Kazuaki Chayama

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Gastric carcinoma occurs in response to chronic inflammation of gastric mucosa infected with Helicobacter pylori. It is not known how cytokines affect the growth and progression of gastric carcinoma.

Materials And Methods: We measured tissue concentrations of the proinflammatory cytokines interleukin (IL)-1beta and IL-6 in gastric carcinoma and investigated the correlation between the levels of these cytokines and clinicopathological features. Biopsy specimens of tumors or adjacent normal mucosa were obtained from 42 Japanese patients with gastric carcinoma. Tissue levels of IL-1beta and IL-6 were measured by enzyme-linked immunosorbent assay.

Results: IL-1beta levels were significantly higher in the neoplasm than in the corresponding normal mucosa. The IL-6 levels in the neoplasm correlated significantly with the depth of invasion and lymphatic invasion. High levels of IL-1beta and IL-6 were characteristic of non-scirrhous type gastric carcinoma.

Conclusion: These results suggest that IL-1beta and IL-6 are involved in the growth and progression of human gastric carcinoma.

Citing Articles

Weight-centric prevention of cancer.

Anazco D, Acosta A, Cathcart-Rake E, DAndre S, Hurtado M Obes Pillars. 2024; 10:100106.

PMID: 38495815 PMC: 10943063. DOI: 10.1016/j.obpill.2024.100106.

Interleukin-6 as a Predictive Factor of Pathological Response to FLOT Regimen Systemic Treatment in Locally Advanced Gastroesophageal Junction or Gastric Cancer Patients.

Marcisz-Grzanka K, Kotowicz B, Nowak A, Winiarek M, Fuksiewicz M, Kowalska M Cancers (Basel). 2024; 16(4).

PMID: 38398148 PMC: 10887209. DOI: 10.3390/cancers16040757.

Platelets as a prognostic factor for patients with adenocarcinoma of the gastroesophageal junction.

Feka J, Jomrich G, Winkler D, Ilhan-Mutlu A, Kristo I, Paireder M Langenbecks Arch Surg. 2023; 408(1):351.

PMID: 37673810 PMC: 10482770. DOI: 10.1007/s00423-023-03093-y.

Impact of umbilical cord mesenchymal stromal/stem cell secretome and cord blood serum in prostate cancer progression.

Sousa A, Coelho P, Leite F, Teixeira C, Rocha A, Santos I Hum Cell. 2023; 36(3):1160-1172.

PMID: 36806993 PMC: 10110723. DOI: 10.1007/s13577-023-00880-z.

Role of Mean Platelet Volume in the Prognosis of Gallbladder Carcinoma: A Tertiary Centre Experience.

Bv P, Anwar A, Harsha R, Arakeri P, Jonnada P Cureus. 2021; 13(7):e16389.

PMID: 34408942 PMC: 8363057. DOI: 10.7759/cureus.16389.