Cerebral MRI Findings in Very-low-birth-weight and Small-for-gestational-age Children at 15 Years of Age

Overview

Journal Pediatr Radiol

Specialty Pediatrics

Date 2005 May 3

PMID 15864579

Citations 17

Authors

Jon S Skranes

Marit Martinussen

Olaug Smevik

Gunnar Myhr

Marit Indredavik

Torstein Vik

Ann-Mari Brubakk

Affiliations

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Abstract

Background: A high prevalence of abnormal cerebral MRI findings has been reported in low-birth-weight children.

Objective: To compare MRI findings in very-low-birth-weight (VLBW) and term small-for-gestational-age (SGA) children with controls in early adolescence.

Materials And Methods: Cerebral MRI was used to examine 55 VLBW, 54 SGA and 66 controls at 15 years of age. The MR images were qualitatively assessed, and size of ventricles, white-matter and grey-matter abnormalities were reported.

Results: The VLBW teenagers had a higher prevalence of various MRI abnormalities than SGA children and controls. Dilation of the ventricular system, especially of the occipital horns, was found in 82% of the VLBW group, in 19% of the SGA group and in 21% of controls. White-matter reduction was found in 53% of the VLBW, in 6% of the SGA and in 2% of controls. Corpus callosum thinning was found in 47% of the VLBW, in 2% of the SGA and in 6% of controls. Periventricular gliosis was found in 29% of the VLBW, in 4% of the SGA and in 8% of controls.

Conclusions: Cerebral MRI pathology in white matter is a common finding in VLBW teenagers. The findings may indicate minor perinatal PVL with resulting loss of white-matter tissue and ventricular dilation.

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References

Skranes J, Vik T, Nilsen G, Smevik O, Andersson H, Rinck P . Cerebral magnetic resonance imaging (MRI) and mental and motor function of very low birth weight infants at one year of corrected age. Neuropediatrics. 1993; 24(5):256-62. DOI: 10.1055/s-2008-1071553. View

Maalouf E, Duggan P, Rutherford M, Counsell S, Fletcher A, Battin M . Magnetic resonance imaging of the brain in a cohort of extremely preterm infants. J Pediatr. 1999; 135(3):351-7. DOI: 10.1016/s0022-3476(99)70133-2. View

Hollo O, Rautava P, Korhonen T, Helenius H, Kero P, Sillanpaa M . Academic achievement of small-for-gestational-age children at age 10 years. Arch Pediatr Adolesc Med. 2002; 156(2):179-87. DOI: 10.1001/archpedi.156.2.179. View

Hayakawa K, Kanda T, Hashimoto K, Okuno Y, Yamori Y, Yuge M . MR imaging of spastic diplegia. The importance of corpus callosum. Acta Radiol. 1996; 37(5):830-6. DOI: 10.1177/02841851960373P279. View

Cooke R, Abernethy L . Cranial magnetic resonance imaging and school performance in very low birth weight infants in adolescence. Arch Dis Child Fetal Neonatal Ed. 1999; 81(2):F116-21. PMC: 1720984. DOI: 10.1136/fn.81.2.f116. View

Paz I, Gale R, Laor A, Danon Y, Stevenson D, Seidman D . The cognitive outcome of full-term small for gestational age infants at late adolescence. Obstet Gynecol. 1995; 85(3):452-6. DOI: 10.1016/0029-7844(94)00430-l. View

Sommerfelt K, Sonnander K, Skranes J, Andersson H, Ahlsten G, Ellertsen B . Neuropsychologic and motor function in small-for-gestation preschoolers. Pediatr Neurol. 2002; 26(3):186-91. DOI: 10.1016/s0887-8994(01)00381-2. View

Sommerfelt K, Andersson H, Sonnander K, Ahlsten G, Ellertsen B, Markestad T . Cognitive development of term small for gestational age children at five years of age. Arch Dis Child. 2000; 83(1):25-30. PMC: 1718382. DOI: 10.1136/adc.83.1.25. View

Strauss R . Adult functional outcome of those born small for gestational age: twenty-six-year follow-up of the 1970 British Birth Cohort. JAMA. 2000; 283(5):625-32. DOI: 10.1001/jama.283.5.625. View

10.

Olsen P, Vainionpaa L, Paakko E, Korkman M, Pyhtinen J, Jarvelin M . Psychological findings in preterm children related to neurologic status and magnetic resonance imaging. Pediatrics. 1998; 102(2 Pt 1):329-36. DOI: 10.1542/peds.102.2.329. View

11.

Bakketeig L, Jacobsen G, Hoffman H, Lindmark G, Bergsjo P, MOLNE K . Pre-pregnancy risk factors of small-for-gestational age births among parous women in Scandinavia. Acta Obstet Gynecol Scand. 1993; 72(4):273-9. DOI: 10.3109/00016349309068037. View

12.

Childs A, Cornette L, Ramenghi L, Tanner S, Arthur R, Martinez D . Magnetic resonance and cranial ultrasound characteristics of periventricular white matter abnormalities in newborn infants. Clin Radiol. 2001; 56(8):647-55. DOI: 10.1053/crad.2001.0754. View

13.

Skranes J, Vik T, Nilsen G, Smevik O, Andersson H, Brubakk A . Cerebral magnetic resonance imaging and mental and motor function of very low birth weight children at six years of age. Neuropediatrics. 1997; 28(3):149-54. DOI: 10.1055/s-2007-973692. View

14.

DUBOWITZ L, Bydder G, Mushin J . Developmental sequence of periventricular leukomalacia. Correlation of ultrasound, clinical, and nuclear magnetic resonance functions. Arch Dis Child. 1985; 60(4):349-55. PMC: 1777237. DOI: 10.1136/adc.60.4.349. View

15.

Peterson B, Vohr B, Staib L, Cannistraci C, Dolberg A, Schneider K . Regional brain volume abnormalities and long-term cognitive outcome in preterm infants. JAMA. 2000; 284(15):1939-47. DOI: 10.1001/jama.284.15.1939. View

16.

Stewart A, Rifkin L, Amess P, Kirkbride V, Townsend J, Miller D . Brain structure and neurocognitive and behavioural function in adolescents who were born very preterm. Lancet. 1999; 353(9165):1653-7. DOI: 10.1016/s0140-6736(98)07130-x. View

17.

Kutschera J, Urlesberger B, Maurer U, Muller W . [Small for gestational age - Somatic, neurological and cognitive development until adulthood]. Z Geburtshilfe Neonatol. 2002; 206(2):65-71. DOI: 10.1055/s-2002-30139. View

18.

Allin M, Henderson M, Suckling J, Nosarti C, Rushe T, Fearon P . Effects of very low birthweight on brain structure in adulthood. Dev Med Child Neurol. 2004; 46(1):46-53. DOI: 10.1017/s0012162204000088. View

19.

Saeed N, Cowan F, Rutherford M, Edwards A . Reduced development of cerebral cortex in extremely preterm infants. Lancet. 2000; 356(9236):1162-3. DOI: 10.1016/s0140-6736(00)02761-6. View

20.

Arends N, V d Lip W, Robben S, Hokken-Koelega A . MRI findings of the pituitary gland in short children born small for gestational age (SGA) in comparison with growth hormone-deficient (GHD) children and children with normal stature. Clin Endocrinol (Oxf). 2002; 57(6):719-24. DOI: 10.1046/j.1365-2265.2002.01605.x. View