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A Segmental Pattern of Alkaline Phosphatase Activity Within the Notochord Coincides with the Initial Formation of the Vertebral Bodies

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Journal J Anat
Date 2005 Apr 29
PMID 15857363
Citations 24
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Abstract

This study shows that segmental expression of alkaline phosphatase (ALP) activity by the notochord of the Atlantic salmon (Salmo salar L.) coincides with the initial mineralization of the vertebral body (chordacentrum), and precedes ALP expression by presumed somite-derived cells external to the notochordal sheath. The early expression of ALP indicates that the notochord plays an instructive role in the segmental patterning of the vertebral column. The chordacentra form segmentally as mineralized rings within the notochordal sheath, and ALP activity spreads within the chordoblast layer from ventral to dorsal, displaying the same progression and spatial distribution as the mineralization process. No ALP activity was observed in sclerotomal mesenchyme surrounding the notochordal sheath during initial formation of the chordacentra. Our results support previous findings indicating that the chordoblasts initiate a segmental differentiation of the notochordal sheath into chordacentra and intervertebral regions.

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References
1.
van Eeden F, Granato M, Schach U, Brand M, Furutani-Seiki M, Haffter P . Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development. 1996; 123:153-64. DOI: 10.1242/dev.123.1.153. View

2.
Bagnall K, Higgins S, Sanders E . The contribution made by a single somite to the vertebral column: experimental evidence in support of resegmentation using the chick-quail chimaera model. Development. 1988; 103(1):69-85. DOI: 10.1242/dev.103.1.69. View

3.
Ekanayake S, Hall B . Ultrastructure of the osteogenesis of acellular vertebral bone in the Japanese medaka, Oryzias latipes (Teleostei, Cyprinidontidae). Am J Anat. 1988; 182(3):241-9. DOI: 10.1002/aja.1001820305. View

4.
Keynes R, Stern C . Mechanisms of vertebrate segmentation. Development. 1988; 103(3):413-29. DOI: 10.1242/dev.103.3.413. View

5.
Jiang D, Munro E, Smith W . Ascidian prickle regulates both mediolateral and anterior-posterior cell polarity of notochord cells. Curr Biol. 2005; 15(1):79-85. DOI: 10.1016/j.cub.2004.12.041. View