Vascular Endothelial Growth Factor Plays an Important Autocrine/paracrine Role in the Progression of Osteoarthritis

Overview

Journal Histochem Cell Biol

Publisher Springer

Specialties Biochemistry
Cell Biology

Date 2005 Apr 28

PMID 15856277

Citations 30

Authors

Eiji Tanaka

Junko Aoyama

Mutsumi Miyauchi

Takashi Takata

Koichi Hanaoka

Tatsunori Iwabe

Kazuo Tanne

Affiliations

Soon will be listed here.

Abstract

Vascular endothelial growth factor (VEGF) plays an essential role in the angiogenesis of growing cartilage. Although VEGF expression in cartilage vanishes in normal adults, VEGF is known to be expressed in chondrocytes of osteoarthritic (OA) cartilage. As little information is available on the VEGF expression in the cartilage of OA-like lesions of the temporomandibular joint (TMJ), VEGF expression in the condylar cartilage of TMJs of rats affected with OA was examined. To evoke OA, mechanical stress was applied by forced jaw opening for 10 or 20 days. After 20 days, marked OA-like lesions were observed in the condyle. VEGF was expressed in the chondrocytes of the mature and hypertrophic cell layers of the intermediate and posterior region of the condyle. The percentage of VEGF immunopositive chondrocytes significantly increased with the period of applied mechanical stress. Furthermore, tartrate-resistant acid phosphatase (TRAP) staining of the condylar cartilage showed significant increment of osteoclasts in the mineralized layer subjacent to the hypertrophic layer where high VEGF expression could be detected. The results suggest that VEGF plays an important role in the progression of OA.

Citing Articles

The Temporomandibular Joint and the Human Body: A New Perspective on Cross Talk.

Abbass M, Rady D, El Moshy S, Radwan I, Wadan A, Dorfer C Dent J (Basel). 2024; 12(11).

PMID: 39590407 PMC: 11592717. DOI: 10.3390/dj12110357.

Excessive load promotes temporomandibular joint chondrocyte apoptosis via Piezo1/endoplasmic reticulum stress pathway.

Wang X, Tao J, Zhou J, Shu Y, Xu J J Cell Mol Med. 2024; 28(11):e18472.

PMID: 38842129 PMC: 11154833. DOI: 10.1111/jcmm.18472.

Bone marrow lesions in osteoarthritis: From basic science to clinical implications.

Shi X, Mai Y, Fang X, Wang Z, Xue S, Chen H Bone Rep. 2023; 18:101667.

PMID: 36909666 PMC: 9996250. DOI: 10.1016/j.bonr.2023.101667.

Association between Common Variants in Gene and the Susceptibility of Primary Knee Osteoarthritis.

Saetan N, Honsawek S, Tanavalee A, Ngarmukos S, Yuktanandana P, Poovorawan Y Cartilage. 2022; 13(4):66-76.

PMID: 36314121 PMC: 9924987. DOI: 10.1177/19476035221132260.

Wnt/β-catenin signaling pathway is activated in the progress of mandibular condylar cartilage degeneration and subchondral bone loss induced by overloaded functional orthopedic force (OFOF).

He Z, Liu M, Zhang Q, Tian Y, Wang L, Yan X Heliyon. 2022; 8(10):e10847.

PMID: 36262297 PMC: 9573886. DOI: 10.1016/j.heliyon.2022.e10847.

References

Wong M, Siegrist M, Goodwin K . Cyclic tensile strain and cyclic hydrostatic pressure differentially regulate expression of hypertrophic markers in primary chondrocytes. Bone. 2003; 33(4):685-93. DOI: 10.1016/s8756-3282(03)00242-4. View

Freemont A, Hampson V, Tilman R, Goupille P, Taiwo Y, Hoyland J . Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific. Ann Rheum Dis. 1997; 56(9):542-9. PMC: 1752435. DOI: 10.1136/ard.56.9.542. View

Enomoto H, Inoki I, Komiya K, Shiomi T, Ikeda E, Obata K . Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage. Am J Pathol. 2003; 162(1):171-81. PMC: 1851114. DOI: 10.1016/s0002-9440(10)63808-4. View

Descalzi Cancedda F, Melchiori A, Benelli R, Gentili C, Masiello L, Campanile G . Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. Eur J Cell Biol. 1995; 66(1):60-8. View

Horner A, Bishop N, Bord S, Beeton C, Kelsall A, Coleman N . Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage. J Anat. 1999; 194 ( Pt 4):519-24. PMC: 1467951. DOI: 10.1046/j.1469-7580.1999.19440519.x. View

Fujisawa T, Kuboki T, Kasai T, Sonoyama W, Kojima S, Uehara J . A repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint. J Dent Res. 2003; 82(9):731-5. DOI: 10.1177/154405910308200914. View

Niida S, Kaku M, Amano H, Yoshida H, Kataoka H, Tanne K . Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med. 1999; 190(2):293-8. PMC: 2195572. DOI: 10.1084/jem.190.2.293. View

von der Mark K, Kirsch T, Nerlich A, Kuss A, Weseloh G, Gluckert K . Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy. Arthritis Rheum. 1992; 35(7):806-11. DOI: 10.1002/art.1780350715. View

Radin E, Paul I . Response of joints to impact loading. I. In vitro wear. Arthritis Rheum. 1971; 14(3):356-62. DOI: 10.1002/art.1780140306. View

10.

Forsythe J, Jiang B, Iyer N, Agani F, Leung S, Koos R . Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996; 16(9):4604-13. PMC: 231459. DOI: 10.1128/MCB.16.9.4604. View

11.

Leonardi R, Lo Muzio L, Bernasconi G, Caltabiano C, PIACENTINI C, Caltabiano M . Expression of vascular endothelial growth factor in human dysfunctional temporomandibular joint discs. Arch Oral Biol. 2003; 48(3):185-92. DOI: 10.1016/s0003-9969(02)00207-8. View

12.

Moses M, Wiederschain D, Wu I, Fernandez C, Ghazizadeh V, Lane W . Troponin I is present in human cartilage and inhibits angiogenesis. Proc Natl Acad Sci U S A. 1999; 96(6):2645-50. PMC: 15822. DOI: 10.1073/pnas.96.6.2645. View

13.

Pufe T, Petersen W, Tillmann B, Mentlein R . The angiogenic peptide vascular endothelial growth factor is expressed in foetal and ruptured tendons. Virchows Arch. 2001; 439(4):579-85. DOI: 10.1007/s004280100422. View

14.

Gerber H, Vu T, Ryan A, Kowalski J, Werb Z, Ferrara N . VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med. 1999; 5(6):623-8. DOI: 10.1038/9467. View

15.

Aoyama J, Tanaka E, Miyauchi M, Takata T, Hanaoka K, Hattori Y . Immunolocalization of vascular endothelial growth factor in rat condylar cartilage during postnatal development. Histochem Cell Biol. 2004; 122(1):35-40. DOI: 10.1007/s00418-004-0671-3. View

16.

Pufe T, Lemke A, Kurz B, Petersen W, Tillmann B, Grodzinsky A . Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol. 2003; 164(1):185-92. PMC: 1602231. DOI: 10.1016/S0002-9440(10)63109-4. View

17.

Garcia-Ramirez M, Toran N, Andaluz P, Carrascosa A, Audi L . Vascular endothelial growth factor is expressed in human fetal growth cartilage. J Bone Miner Res. 2000; 15(3):534-40. DOI: 10.1359/jbmr.2000.15.3.534. View

18.

Ohashi N, Robling A, Burr D, Turner C . The effects of dynamic axial loading on the rat growth plate. J Bone Miner Res. 2002; 17(2):284-92. DOI: 10.1359/jbmr.2002.17.2.284. View

19.

Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z . Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 1999; 13(1):9-22. View

20.

Alini M, Marriott A, Chen T, Abe S, Poole A . A novel angiogenic molecule produced at the time of chondrocyte hypertrophy during endochondral bone formation. Dev Biol. 1996; 176(1):124-32. DOI: 10.1006/dbio.1996.9989. View