Effectiveness of Glycerol As a Submucosal Injection for EMR

Overview

Journal Gastrointest Endosc

Specialties Gastroenterology
Pharmacology
Radiology

Date 2005 Apr 28

PMID 15855984

Citations 64

Authors

Toshio Uraoka

Takahiro Fujii

Yutaka Saito

Tetsuya Sumiyoshi

Fabian Emura

Pradeep Bhandari

Takahisa Matsuda

Kuang-I Fu

Daizo Saito

Affiliations

Soon will be listed here.

Abstract

Background: EMR traditionally is performed by using normal saline solution (NS) as the submucosal fluid cushion. It is thought, however, that NS does not maintain the proper mucosal elevation for EMR of large, flat lesions. We investigated the efficacy of glycerol as the submucosal injection solution.

Methods: A total of 110 colorectal laterally spreading tumors (LST) were treated by EMR with glycerol. For comparison, 113 LSTs treated by using NS were studied. The en bloc resection, complete resection, and associated complications rates were evaluated retrospectively.

Observations: The en bloc resection rate in the glycerol group was 63.6% (70/110) compared with 48.9% (55/113) in the NS group (p < 0.05). The complete resection rate in the glycerol group was 45.5% (50/110) compared with 24.6% (28/113) in the NS group (p < 0.01). The associated complications rate was similar in both groups.

Conclusions: It technically was easier and as safe to perform EMR of colorectal LSTs when using glycerol as the submucosal injection solution.

Citing Articles

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Development of a hybrid hydrogel for submucosal injection in endoscopic resection of gastrointestinal neoplasm: From laboratory to clinical trial.

Kang J, Chen P, Chen C, Riley G, Wang Y, Kuo H Endosc Int Open. 2024; 11(11):E1026-E1034.

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A review of hydrogels used in endoscopic submucosal dissection for intraoperative submucosal cushions and postoperative management.

Chen Z, Ding J, Wu C, Wei D, Sun J, Fan H Regen Biomater. 2023; 10:rbad064.

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Endoscopic Mucosal Resection: Best Practices for Gastrointestinal Endoscopists.

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Mann R, Gajendran M, Umapathy C, Perisetti A, Goyal H, Saligram S Front Med (Lausanne). 2022; 8:728704.

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