Tumor Necrosis Factor and Granuloma Biology: Explaining the Differential Infection Risk of Etanercept and Infliximab

Overview

Journal Semin Arthritis Rheum

Specialty Rheumatology

Date 2005 Apr 27

PMID 15852254

Citations 46

Authors

Robert S Wallis

Stefan Ehlers

Affiliations

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Abstract

Several studies show that the risk of granulomatous infections following therapy with the anti-tumor necrosis factor (TNF) antibody infliximab is higher than after treatment with the soluble TNFRp75 immunoglobulin fusion construct etanercept. Therefore, despite sharing a common target, it is possible that the actual mode of action of the 2 biologicals differs in vivo. TNF is known to participate in the induction and maintenance of protective granulomas at multiple steps, and evidence supporting a differential inhibition of TNF bioactivity and signaling by the 2 drugs is discussed.

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