Silent Pituitary Macroadenoma Co-secreting Growth Hormone and Thyroid Stimulating Hormone

Overview

Journal J Clin Neurosci

Specialty Neurology

Date 2005 Apr 27

PMID 15851094

Citations 4

Authors

Orhan Sen

M Eda Ertorer

M Volkan Aydin

Bulent Erdogan

Nur Altinors

Suzan Zorludemir

Nilgun Guvener

Affiliations

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Abstract

Silent pituitary adenomas are a group of tumors showing heterogenous morphological features with no hormonal function observed clinically. To date no explanation has been provided as to why these tumors remain "silent". We report a case of a silent macroadenoma with both growth hormone (GH) and thyroid stimulating hormone (TSH) staining and secretion but with no clinical manifestations, in particular, the absence of features of acromegaly or hyperthyroidism. The relevant literature is reviewed.

Citing Articles

ASSESSMENT AND COMPARISON OF HORMONAL IMMUNOEXPRESSION AND THE CLINICAL PICTURE IN PATIENTS WITH PITUITARY ADENOMAS.

Kwinta B, Myszka A, Krzyzewski R, Klis K, Dragan M, Adamek D Acta Endocrinol (Buchar). 2020; 16(2):148-155.

PMID: 33029230 PMC: 7535894. DOI: 10.4183/aeb.2020.148.

Clinically silent somatotroph adenomas are common.

Wade A, Baccon J, Grady M, Judy K, ORourke D, Snyder P Eur J Endocrinol. 2011; 165(1):39-44.

PMID: 21493729 PMC: 3118490. DOI: 10.1530/EJE-11-0216.

Clinicopathological characterization of TSH-producing adenomas: special reference to TSH-immunoreactive but clinically non-functioning adenomas.

Wang E, Qian Z, Yamada S, Rahman M, Inosita N, Kageji T Endocr Pathol. 2009; 20(4):209-20.

PMID: 19774499 DOI: 10.1007/s12022-009-9094-y.

Modification of hormonal secretion in clinically silent pituitary adenomas.

Daems T, Verhelst J, Michotte A, Abrams P, Ridder D, Abs R Pituitary. 2008; 12(1):80-6.

PMID: 18350381 DOI: 10.1007/s11102-008-0085-7.