The Effect of Noninherited Maternal Antigens in Allogeneic Transplantation

Overview

Journal Semin Hematol

Specialty Hematology

Date 2005 Apr 23

PMID 15846576

Citations 9

Authors

J J van Rood

D L Roelen

F H J Claas

Affiliations

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Abstract

Confrontation of the unborn child immune system with the noninherited maternal antigens (NIMAs) has a lifelong modulating impact on the immune response of the child against the NIMAs. In this review we summarize the clinical evidence for the existence of the NIMA effect, discuss the possible cellular and molecular basis of the phenomenon, and outline the necessity of further clinical research.

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