The Bartonella Vinsonii Subsp. Arupensis Immunodominant Surface Antigen BrpA Gene, Encoding a 382-kilodalton Protein Composed of Repetitive Sequences, is a Member of a Multigene Family Conserved Among Bartonella Species

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2005 Apr 23

PMID 15845521

Citations 12

Authors

Robert D Gilmore Jr

Travis M Bellville

Steven L Sviat

Michael Frace

Affiliations

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Abstract

Bartonella proteins that elicit an antibody response during an infection are poorly defined; therefore, to characterize antigens recognized by the host, a Bartonella genomic expression library was screened with serum from an infected mouse. This process led to the discovery of a Bartonella vinsonii subsp. arupensis gene encoding a 382-kDa protein, part of a gene family encoding large proteins, each containing multiple regions of repetitive segments. The genes were termed brpA to -C (bartonella repeat protein) and bore significant similarity to genes encoding the BadA adhesin protein and members of the variably expressed outer membrane protein family of proteins from Bartonella henselae and Bartonella quintana, respectively.

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