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The Dopamine Transporter: Role in Neurotoxicity and Human Disease

Overview
Specialties Pharmacology
Toxicology
Date 2005 Apr 23
PMID 15845424
Citations 34
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Abstract

The dopamine transporter (DAT) is a plasma membrane transport protein expressed exclusively within a small subset of CNS neurons. It plays a crucial role in controlling dopamine-mediated neurotransmission and a number of associated behaviors. This review focuses on recent data elucidating the role of the dopamine transporter in neurotoxicity and a number of CNS disorders, including Parkinson disease, drug abuse, and attention deficit hyperactivity disorder (ADHD).

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