Cremastrine, a Pyrrolizidine Alkaloid from Cremastra Appendiculata

Overview

Journal J Nat Prod

Date 2005 Apr 23

PMID 15844951

Citations 7

Authors

Yoshitaka Ikeda

Hikaru Nonaka

Tamotsu Furumai

Yasuhiro Igarashi

Affiliations

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Abstract

A new pyrrolizidine alkaloid, cremastrine (1), was isolated from the bulbs of Cremastra appendiculata. Its configuration was determined by spectroscopic and chemical analyses. Compound 1 inhibited the binding of tritium-labeled N-methylscopolamine to the muscarinic M3 receptor with a K(i) value of 126 nM.

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