Adenoma with Gastric Differentiation (so-called Pyloric Gland Adenoma) in a Heterotopic Gastric Corpus Mucosa in the Rectum

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2005 Apr 20

PMID 15838648

Citations 14

Authors

M Vieth

R Kushima

J P A de Jonge

F Borchard

F Oellig

M Stolte

Affiliations

Soon will be listed here.

Abstract

In a 46-year-old man, a pedunculated rectal polyp measuring 3.0x3.0x2.0 cm was diagnosed histologically as a pyloric gland-type adenoma arising in heterotopic gastric corpus mucosa. The luminal site was covered by glands of the gastric foveolar type, displaying focal marked proliferation interpreted as low-grade intraepithelial neoplasia. A bidirectional gastric differentiation was found: most lower glandular structures showed positivity for the deep gastric mucin core protein Muc 6 and superficial positivity for gastric foveolar epithelium mucin core protein Muc 5AC. Pyloric gland adenoma has so far been described in one larger series only and a few case reports of the stomach, gallbladder, pancreatic duct and within heterotopic gastric corpus mucosa of the duodenal bulb. The present case report is the first case of a pyloric gland-type adenoma within a gastric corpus heterotopia of the rectal mucosa.

Citing Articles

Mass-Forming Gastric Heterotopia of the Rectum: A Series of 3 Cases from a Single Tertiary Health Center.

Covington J, Zong Y, Talat A, Strock C, Tomaszewicz K, Zivny J Am J Case Rep. 2022; 23:e936631.

PMID: 35881563 PMC: 9339256. DOI: 10.12659/AJCR.936631.

Pyloric Gland Adenoma of the Esophagus Treated by Endoscopic Submucosal Dissection: A Case Report.

Park K, Kim D, Lee S, Lee H, Jung H Gut Liver. 2022; 16(3):483-486.

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Colonic tubular adenoma with incidental oxyntic gastric heterotopia.

Val-Bernal J, Cagigal M, Mayorga M, Cuadrado M, Rodriguez-Escaja C Rom J Morphol Embryol. 2021; 62(1):313-318.

PMID: 34609438 PMC: 8597387. DOI: 10.47162/RJME.62.1.35.

[Heterotopic tissue in the gastrointestinal tract].

Offner F, Langner C Pathologe. 2018; 39(5):402-408.

PMID: 30105611 DOI: 10.1007/s00292-018-0466-2.

Gastric heterotopia in rectum: A literature review and its diagnostic pitfall.

Dinarvand P, Vareedayah A, Phillips N, Hachem C, Lai J SAGE Open Med Case Rep. 2017; 5:2050313X17693968.

PMID: 28321304 PMC: 5347492. DOI: 10.1177/2050313X17693968.

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