Melanocyte Stem Cell Maintenance and Hair Graying

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2005 Apr 12

PMID 15820674

Citations 30

Authors

Eirikur Steingrimsson

Neal G Copeland

Nancy A Jenkins

Affiliations

Soon will be listed here.

Abstract

Hair graying is an obvious sign of human aging, yet little was known about its causes. Two recent papers provide compelling evidence that hair graying is due to incomplete melanocyte stem cell maintenance and identify Pax3 and Mitf as key molecules that help regulate the balance between melanocyte stem cell maintenance and differentiation.

Citing Articles

Epidermal stem cells: skin surveillance and clinical perspective.

Tang X, Wang J, Chen J, Liu W, Qiao P, Quan H J Transl Med. 2024; 22(1):779.

PMID: 39169334 PMC: 11340167. DOI: 10.1186/s12967-024-05600-1.

Loss of Pax3 causes reduction of melanocytes in the developing mouse cochlea.

Udagawa T, Takahashi E, Tatsumi N, Mutai H, Saijo H, Kondo Y Sci Rep. 2024; 14(1):2210.

PMID: 38278860 PMC: 10817906. DOI: 10.1038/s41598-024-52629-9.

Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence.

Ungvari A, Kiss T, Gulej R, Tarantini S, Csik B, Yabluchanskiy A Geroscience. 2024; 46(3):3105-3122.

PMID: 38182857 PMC: 11009199. DOI: 10.1007/s11357-023-01042-7.

Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress.

Feng Z, Qin Y, Jiang G Int J Biol Sci. 2023; 19(14):4588-4607.

PMID: 37781032 PMC: 10535703. DOI: 10.7150/ijbs.86911.

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity.

Casalou C, Mayatra J, Tobin D Int J Mol Sci. 2023; 24(16).

PMID: 37628992 PMC: 10454394. DOI: 10.3390/ijms241612809.